LDN–212854
cas: 1432597-26-6 — see every product listed under this CAS number, including other names
LDN–212854 (CAS 1432597-26-6) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 5mg, 10mM (in 1ml dmso), 50mg. Offered by: GLPBio.
| brand | GLPBio |
|---|---|
| catalog number | GC17035-10 |
| cas | 1432597-26-6 |
| size | 10mg |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| GLPBio | 10mg | 1004.24 Pln | |
| GLPBio | 5mg | 751.50 Pln | |
| GLPBio | 10mM (in 1ml dmso) | 784.26 Pln | |
| GLPBio | 50mg | 2408.39 Pln |
properties
| purity | No data |
|---|---|
| delivery time | To be confirmed by Chemat |
LDN-212854 is a member of the class of quinolines that is quinoline substituted by a 6-[4-(piperazin-1-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl group at position 5. It is a potent ALK inhibitor (IC50 values of 2.4, 1.3, 85.8, 2,133 and 9,276 nM for ALK1, ALK2, ALK3, ALK4 and ALK5, respectively). It has a role as an EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor, an antineoplastic agent and an angiogenesis inhibitor. It is a member of quinolines, a pyrazolopyrimidine and a N-arylpiperazine.
Source: ChEBI
| Molecular formula | C25H22N6 |
|---|---|
| Molecular weight | 406.5 g/mol |
| IUPAC name | 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline |
| InChIKey | BBDGBGOVJPEFBT-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=C6C=CC=NC6=CC=C5)N=C3 |
Computed by PubChem (NCBI)
Synonyms:
5-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline, 5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline, orb1226289, orb1307185, s7147, 5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-alpha]pyrimidin-3-yl]quinoline, quinoline, 5-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-