Products 1432597-26-6

CAS 1432597-26-6 appears in our catalog under these names: 5-(6-(4-(1-Piperazinyl)phenyl)pyrazolo(1,5-a)pyrimidin-3-yl)quinoline, LDN-212854/ 99.38% (existing batch purity), LDN–212854, LDN-212854, 5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 98%, 98%. Offered by: TRC, TargetMol, GLPBio, Biosynth, Chemat. Available pack sizes: 500mg, 2mg, 5mg, 10mg, 25mg, 50mg, 100mg, 200mg.

5-(6-(4-(1-Piperazinyl)phenyl)pyrazolo(1,5-a)pyrimidin-3-yl)quinoline
TRC
  • size: 500mg
  • Variants: 1
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LDN-212854/ 99.38% (existing batch purity)
TargetMol
  • size: 2mg, 5mg, 10mg, 25mg
  • Variants: 7
from 419.13
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LDN–212854
GLPBio
  • size: 10mg, 5mg, 10mM (in 1ml dmso), 50mg
  • Variants: 4
from 751.50
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LDN-212854
Biosynth
  • size: 50mg, 25mg, 100mg
  • Variants: 3
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5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 98%, 98%
Chemat
  • size: 5mg, 10mg, 50mg, 25mg
  • Variants: 4
from 352.40
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LDN-212854, 99.62%
MedChemExpress
  • size: 100 mg, 1 g, 10 mg, 10mM/1mL
  • Variants: 7
from 705.14
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Structural formula: {0} (CAS {1})

LDN-212854 is a member of the class of quinolines that is quinoline substituted by a 6-[4-(piperazin-1-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl group at position 5. It is a potent ALK inhibitor (IC50 values of 2.4, 1.3, 85.8, 2,133 and 9,276 nM for ALK1, ALK2, ALK3, ALK4 and ALK5, respectively). It has a role as an EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor, an antineoplastic agent and an angiogenesis inhibitor. It is a member of quinolines, a pyrazolopyrimidine and a N-arylpiperazine.

Source: ChEBI

Identity
Molecular formulaC25H22N6
Molecular weight406.5 g/mol
IUPAC name5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
InChIKeyBBDGBGOVJPEFBT-UHFFFAOYSA-N
SMILESC1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=C6C=CC=NC6=CC=C5)N=C3

Computed by PubChem (NCBI)

Synonyms: 5-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline, 5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline, orb1226289, orb1307185, s7147, 5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-alpha]pyrimidin-3-yl]quinoline, quinoline, 5-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-
Isomers (same molecular formula)
4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline C25H22N6