LY 2090314

cas: 603288-22-8 — see every product listed under this CAS number, including other names

LY 2090314 (CAS 603288-22-8) is a chemical reagent available from Chemat. Available pack sizes: 25mg, 10mg, 50mg. Offered by: TRC, Biosynth.

brandTRC
catalog numberTRC-L395020-25MG
cas603288-22-8
size25mg
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Biosynth 50mg price on request

properties

purityNo data
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

LY-2090314 is a member of the class of diazepinoindoles that is 1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indole substituted by piperidin-1-ylcarbonyl, 4-(imidazo[1,2-a]pyridin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl and fluoro groups at position 2, 7 and 9, respectively. It is a potent ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 values of 1.5 nM and 0.9 nM for GSK-3alpha and GSK-3beta. The drug is in clinical development for the treatment of advanced/metastatic cancer. It has a role as a Wnt signalling activator, an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a diazepinoindole, an imidazopyridine, a member of ureas, a piperidinecarboxamide, a member of maleimides and a member of monofluorobenzenes.

Source: ChEBI

Identity
Molecular formulaC28H25FN6O3
Molecular weight512.5 g/mol
IUPAC name3-[6-fluoro-10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione
InChIKeyHRJWTAWVFDCTGO-UHFFFAOYSA-N
SMILESC1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7

Computed by PubChem (NCBI)

Synonyms: Kinome_3681, orb1224501, orb1307529, s7063, ?-(Trichloromethyl)-4-pyridineethanol
Related forms of this compound
3-[10-(2,2,3,3,4,4,5,5,6,6-decadeuteriopiperidine-1-carbonyl)-6-fluoro-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione C28H25FN6O3

Also listed as

LY2090314/ 99.88% (existing batch purity) TargetMol CAS 603288-22-8
LY2090314 GLPBio CAS 603288-22-8
LY2090314 99% Ambeed CAS 603288-22-8
3-[9-Fluoro-1,2,3,4-Tetrahydro-2-(1-Piperidinylcarbonyl)Pyrrolo[3,2,1-Jk][1,4]Benzodiazepin-7-Yl]-4-Imidazo[1,2-A]Pyridin-3-Yl-1H-Pyrrole-2,5-Dione, 99%, 99% Chemat CAS 603288-22-8
LY2090314, 99.85% MedChemExpress CAS 603288-22-8
LY2090314 (GMP) MedChemExpress CAS 603288-22-8