LY2090314
cas: 603288-22-8 — see every product listed under this CAS number, including other names
LY2090314 (CAS 603288-22-8) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 100mg, 25mg, 5mg. Offered by: GLPBio.
| brand | GLPBio |
|---|---|
| catalog number | GC17187-10 |
| cas | 603288-22-8 |
| size | 10mg |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| GLPBio | 10mg | 1008.92 Pln | |
| GLPBio | 100mg | 2951.33 Pln | |
| GLPBio | 25mg | 1631.43 Pln | |
| GLPBio | 5mg | 919.99 Pln |
properties
| purity | No data |
|---|---|
| delivery time | To be confirmed by Chemat |
LY-2090314 is a member of the class of diazepinoindoles that is 1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indole substituted by piperidin-1-ylcarbonyl, 4-(imidazo[1,2-a]pyridin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl and fluoro groups at position 2, 7 and 9, respectively. It is a potent ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 values of 1.5 nM and 0.9 nM for GSK-3alpha and GSK-3beta. The drug is in clinical development for the treatment of advanced/metastatic cancer. It has a role as a Wnt signalling activator, an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a diazepinoindole, an imidazopyridine, a member of ureas, a piperidinecarboxamide, a member of maleimides and a member of monofluorobenzenes.
Source: ChEBI
| Molecular formula | C28H25FN6O3 |
|---|---|
| Molecular weight | 512.5 g/mol |
| IUPAC name | 3-[6-fluoro-10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione |
| InChIKey | HRJWTAWVFDCTGO-UHFFFAOYSA-N |
| SMILES | C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7 |
Computed by PubChem (NCBI)