Products 603288-22-8
CAS 603288-22-8 appears in our catalog under these names: LY 2090314, LY2090314/ 99.88% (existing batch purity), LY2090314, LY2090314 99%, 3-[9-Fluoro-1,2,3,4-Tetrahydro-2-(1-Piperidinylcarbonyl)Pyrrolo[3,2,1-Jk][1,4]Benzodiazepin-7-Yl]-4-Imidazo[1,2-A]Pyridin-3-Yl-1H-Pyrrole-2,5-Dione, 99%, 99%. Offered by: TRC, TargetMol, GLPBio, Biosynth, Ambeed. Available pack sizes: 25mg, 1mg, 2mg, 5mg, 10mg, 50mg, 100mg, 250mg.
LY-2090314 is a member of the class of diazepinoindoles that is 1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indole substituted by piperidin-1-ylcarbonyl, 4-(imidazo[1,2-a]pyridin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl and fluoro groups at position 2, 7 and 9, respectively. It is a potent ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 values of 1.5 nM and 0.9 nM for GSK-3alpha and GSK-3beta. The drug is in clinical development for the treatment of advanced/metastatic cancer. It has a role as a Wnt signalling activator, an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a diazepinoindole, an imidazopyridine, a member of ureas, a piperidinecarboxamide, a member of maleimides and a member of monofluorobenzenes.
Source: ChEBI
| Molecular formula | C28H25FN6O3 |
|---|---|
| Molecular weight | 512.5 g/mol |
| IUPAC name | 3-[6-fluoro-10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione |
| InChIKey | HRJWTAWVFDCTGO-UHFFFAOYSA-N |
| SMILES | C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7 |
Computed by PubChem (NCBI)