Linsitinib
cas: 867160-71-2 — see every product listed under this CAS number, including other names
Linsitinib (CAS 867160-71-2) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 5mg, 10mM (in 1ml dmso), 50mg. Offered by: GLPBio, Biosynth.
| brand | GLPBio |
|---|---|
| catalog number | GC15749-10 |
| cas | 867160-71-2 |
| size | 10mg |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| GLPBio | 10mg | 1069.77 Pln | |
| GLPBio | 5mg | 770.22 Pln | |
| GLPBio | 10mM (in 1ml dmso) | 854.47 Pln | |
| GLPBio | 50mg | 2085.44 Pln | |
| Biosynth | 10mg | price on request | |
| Biosynth | 50mg | price on request |
properties
| purity | No data |
|---|---|
| delivery time | To be confirmed by Chemat |
Linsitinib is an imidazopyrazine that is imidazo[1,5-a]pyrazine substituted by 2-phenylquinolin-7-yl, cis-3-hydroxy-3-methylcyclobutyl, and amino groups at positions 1, 3, and 8, respectively. It is dual inhibitor of the IGF-1 receptor and insulin receptor (IC50 = 35 and 75 nM, respectively) that was previously in clinical development for the treatment of cancer and thyroid eye disease. It has a role as an antineoplastic agent, an antimycobacterial drug, an apoptosis inducer and an insulin-like growth factor receptor 1 antagonist. It is a member of cyclobutanes, a member of benzenes, a member of quinolines, a tertiary alcohol, an aromatic amine and an imidazopyrazine.
Source: ChEBI
| Molecular formula | C26H23N5O |
|---|---|
| Molecular weight | 421.5 g/mol |
| IUPAC name | 3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol |
| InChIKey | PKCDDUHJAFVJJB-UHFFFAOYSA-N |
| SMILES | CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O |
Computed by PubChem (NCBI)