Products 867160-71-2

CAS 867160-71-2 appears in our catalog under these names: Linsitinib, >95% (HPLC), Linsitinib/ 98%, Linsitinib, Linsitinib 98%, Linsitinib, 98%, 98%. Offered by: TRC, TargetMol, GLPBio, Biosynth, Ambeed. Available pack sizes: 5mg, 2mg, 10mg, 25mg, 50mg, 100mg, 10mM (in 1ml dmso), 1mg.

Linsitinib, >95% (HPLC)
TRC
  • size: 5mg
  • Variants: 1
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Linsitinib/ 98%
TargetMol
  • size: 2mg, 5mg, 10mg, 25mg
  • Variants: 6
from 405.71
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Linsitinib
GLPBio, Biosynth
  • size: 10mg, 5mg, 10mM (in 1ml dmso), 50mg
  • Variants: 6
from 770.22
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Linsitinib 98%
Ambeed
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 8
from 203.50
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Linsitinib, 98%, 98%
Chemat
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 8
from 131.60
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Linsitinib, 99.90%
MedChemExpress
  • size: 5 mg, 10 mg, 100 mg, 10mM/1mL
  • Variants: 6
from 435.79
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Linsitinib (Standard)
MedChemExpress
  • size: 10 mg, 100 mg, 50 mg, 5 mg
  • Variants: 5
from 909.48
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Linsitinib, 98%
Fluorochem
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 7
from 227.02
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Structural formula: {0} (CAS {1})

Linsitinib is an imidazopyrazine that is imidazo[1,5-a]pyrazine substituted by 2-phenylquinolin-7-yl, cis-3-hydroxy-3-methylcyclobutyl, and amino groups at positions 1, 3, and 8, respectively. It is dual inhibitor of the IGF-1 receptor and insulin receptor (IC50 = 35 and 75 nM, respectively) that was previously in clinical development for the treatment of cancer and thyroid eye disease. It has a role as an antineoplastic agent, an antimycobacterial drug, an apoptosis inducer and an insulin-like growth factor receptor 1 antagonist. It is a member of cyclobutanes, a member of benzenes, a member of quinolines, a tertiary alcohol, an aromatic amine and an imidazopyrazine.

Source: ChEBI

Identity
Molecular formulaC26H23N5O
Molecular weight421.5 g/mol
IUPAC name3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol
InChIKeyPKCDDUHJAFVJJB-UHFFFAOYSA-N
SMILESCC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O

Computed by PubChem (NCBI)

Synonyms: Linsitinib, Linsitinib(OSI-906), Kinome_3532, Linsitinib (OSI-906), Linsitinib (USAN/INN), Linsitinib [USAN], Linsitinib [USAN:INN], Linsitinib; OSI-906, LINSITINIB [INN], Linsitinib(OSI-906)?
Related forms of this compound
3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-(trideuteriomethyl)cyclobutan-1-ol C26H23N5O