PD–166866
cas: 192705-79-6 — see every product listed under this CAS number, including other names
PD–166866 (CAS 192705-79-6) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 100mg, 25mg, 5mg, 50mg. Offered by: GLPBio.
| brand | GLPBio |
|---|---|
| catalog number | GC19279-10 |
| cas | 192705-79-6 |
| size | 10mg |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| GLPBio | 10mg | 714.05 Pln | |
| GLPBio | 100mg | 2483.28 Pln | |
| GLPBio | 25mg | 1013.60 Pln | |
| GLPBio | 5mg | 615.76 Pln | |
| GLPBio | 50mg | 1514.42 Pln |
properties
| purity | No data |
|---|---|
| delivery time | To be confirmed by Chemat |
PD-166866 is a member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by an amino group at position 2, 3,5-dimethoxyphenyl group at position 6, and by a (tert-butylcarbamoyl)nitrilo group at position 7. It is a selective ATP competitive inhibitor of the human fibroblast growth factor-1 receptor (FGFR1) tyrosine kinase with an IC50 of 52.4 nM. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an apoptosis inducer. It is a pyridopyrimidine, a member of ureas, a primary arylamine, a dimethoxybenzene and a biaryl.
Source: ChEBI
| Molecular formula | C20H24N6O3 |
|---|---|
| Molecular weight | 396.4 g/mol |
| IUPAC name | 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea |
| InChIKey | NHJSWORVNIOXIT-UHFFFAOYSA-N |
| SMILES | CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=CC(=CC(=C3)OC)OC |
Computed by PubChem (NCBI)