PD-166866, 99.75%
cas: 192705-79-6 — see every product listed under this CAS number, including other names
PD-166866, 99.75% (CAS 192705-79-6) is a chemical reagent available from Chemat. Available pack sizes: 50 mg, 100 mg, 1 mg, 5 mg, 25 mg, 500 mg, 10 mg, 1 g. Offered by: MedChemExpress.
| brand | MedChemExpress |
|---|---|
| catalog number | HY-101296-50 mg |
| cas | 192705-79-6 |
| size | 50 mg |
| availability | In stock |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| MedChemExpress | 50 mg | 1963.67 Pln | |
| MedChemExpress | 100 mg | 2883.18 Pln | |
| MedChemExpress | 1 mg | 277.90 Pln | |
| MedChemExpress | 5 mg | 454.37 Pln | |
| MedChemExpress | 25 mg | 1271.71 Pln | |
| MedChemExpress | 500 mg | 5734.60 Pln | |
| MedChemExpress | 10 mg | 649.42 Pln | |
| MedChemExpress | 1 g | 8038.02 Pln |
properties
| delivery time | 1-2 weeks |
|---|---|
| purity | 99.75% |
PD-166866 is a member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by an amino group at position 2, 3,5-dimethoxyphenyl group at position 6, and by a (tert-butylcarbamoyl)nitrilo group at position 7. It is a selective ATP competitive inhibitor of the human fibroblast growth factor-1 receptor (FGFR1) tyrosine kinase with an IC50 of 52.4 nM. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an apoptosis inducer. It is a pyridopyrimidine, a member of ureas, a primary arylamine, a dimethoxybenzene and a biaryl.
Source: ChEBI
| Molecular formula | C20H24N6O3 |
|---|---|
| Molecular weight | 396.4 g/mol |
| IUPAC name | 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea |
| InChIKey | NHJSWORVNIOXIT-UHFFFAOYSA-N |
| SMILES | CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=CC(=CC(=C3)OC)OC |
Computed by PubChem (NCBI)