Products 192705-79-6
CAS 192705-79-6 appears in our catalog under these names: PD-166866, PD-166866/ 99.98% (existing batch purity), PD–166866, PD 166866, PD-166866 99%. Offered by: TRC, TargetMol, GLPBio, Biosynth, Ambeed. Available pack sizes: 10mg, 2mg, 5mg, 25mg, 50mg, 100mg, 200mg, 0,1g.
PD-166866 is a member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by an amino group at position 2, 3,5-dimethoxyphenyl group at position 6, and by a (tert-butylcarbamoyl)nitrilo group at position 7. It is a selective ATP competitive inhibitor of the human fibroblast growth factor-1 receptor (FGFR1) tyrosine kinase with an IC50 of 52.4 nM. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an apoptosis inducer. It is a pyridopyrimidine, a member of ureas, a primary arylamine, a dimethoxybenzene and a biaryl.
Source: ChEBI
| Molecular formula | C20H24N6O3 |
|---|---|
| Molecular weight | 396.4 g/mol |
| IUPAC name | 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea |
| InChIKey | NHJSWORVNIOXIT-UHFFFAOYSA-N |
| SMILES | CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=CC(=CC(=C3)OC)OC |
Computed by PubChem (NCBI)