PEVONEDISTAT, 99%

cas: 905579-51-3 — see every product listed under this CAS number, including other names

PEVONEDISTAT, 99% (CAS 905579-51-3) is a chemical reagent available from Chemat. Available pack sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Offered by: Fluorochem.

brand	Fluorochem
catalog number	F857134-5MG
cas	905579-51-3
size	5mg
availability	In Stock China

Documents: Safety Data Sheet (MSDS)

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Available pack sizes

brand	size	price
Fluorochem	5mg	747.67 Pln
Fluorochem	10mg	981.96 Pln
Fluorochem	25mg	1632.78 Pln
Fluorochem	50mg	2918.78 Pln
Fluorochem	100mg	4918.08 Pln

properties

purity	99%
dual use	No
currency	EUR
delivery time	3-4 weeks
category	Odczynniki chemiczne

Pevonedistat is a pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine which is substituted by a (1S)-2,3-dihydro-1H-inden-1-ylnitrilo group at position 4 and by a (1S,3S,4S)-3-hydroxy-4-[(sulfamoyloxy)methyl]cyclopentyl group at position 7. It is a potent and selective NEDD8-activating enzyme inhibitor with an IC50 of 4.7 nM, and currently under clinical investigation for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes. It has a role as an antineoplastic agent and an apoptosis inducer. It is a member of cyclopentanols, a pyrrolopyrimidine, a member of indanes, a secondary amino compound and a sulfamidate.

Source: ChEBI

Identity
Molecular formula	C₂₁H₂₅N₅O₄S
Molecular weight	443.5 g/mol
IUPAC name	[(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamate
InChIKey	MPUQHZXIXSTTDU-QXGSTGNESA-N
SMILES	C1CC2=CC=CC=C2[C@H]1NC3=C4C=CN(C4=NC=N3)[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N

Computed by PubChem (NCBI)

Synonyms: Pevonedistat, pevonedistatum, Nedd8-Activating Enzyme Inhibitor MLN4924, Pevonedistat (MLN-4924), Pevonedistat HCl, Pevonedistat [USAN:INN], 3gzn, 905579-51-3 (free base), Pevonedistat; MLN4924, Pevonedistat (USAN/INN)