RG 7388

cas: 1229705-06-9 — see every product listed under this CAS number, including other names

RG 7388 (CAS 1229705-06-9) is a chemical reagent available from Chemat. Available pack sizes: 250mg, 100mg, 500mg, 1000mg. Offered by: Biosynth.

brandBiosynth
catalog numberFR104258-250mg
cas1229705-06-9
size250mg
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Available pack sizes

brand size price
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Biosynth 1000mg price on request

properties

categoryLife Sciences
purityNo data
delivery time4-6 weeks
Structural formula: {0} (CAS {1})

Idasanutlin is an orally available, small molecule, antagonist of MDM2 (mouse double minute 2; Mdm2 p53 binding protein homolog), with potential antineoplastic activity. Idasanutlin binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53. By preventing the MDM2-p53 interaction, p53 is not enzymatically degraded and the transcriptional activity of p53 is restored. This may lead to p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger nuclear phosphoprotein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.

Source: ChEBI

Identity
Molecular formulaC31H29Cl2F2N3O4
Molecular weight616.5 g/mol
IUPAC name4-[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid
InChIKeyTVTXCJFHQKSQQM-LJQIRTBHSA-N
SMILESCC(C)(C)C[C@H]1[C@]([C@H]([C@@H](N1)C(=O)NC2=C(C=C(C=C2)C(=O)O)OC)C3=C(C(=CC=C3)Cl)F)(C#N)C4=C(C=C(C=C4)Cl)F

Computed by PubChem (NCBI)

Synonyms: Idasanutlin, Idasanutlina, Idasanutline, idasanutlinum, Idasanutlin (RG-7388), Idasanutlin (RG7388), C31H29Cl2F2N3O4, Idasanutlin [USAN:INN], IDASANUTLIN [INN], Idasanutlin (USAN/INN)

Also listed as

Idasanutlin TRC CAS 1229705-06-9
RG7388 GLPBio CAS 1229705-06-9
Idasanutlin/ 99.86% (existing batch purity) TargetMol CAS 1229705-06-9
Idasanutlin 98% Ambeed CAS 1229705-06-9
Idasanutlin, 99.93% MedChemExpress CAS 1229705-06-9
Idasanutlin (Standard) MedChemExpress CAS 1229705-06-9
4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid, 98%, 98% Chemat CAS 1229705-06-9
Idasanutlin, 98% Fluorochem CAS 1229705-06-9