RG7388

cas: 1229705-06-9 — see every product listed under this CAS number, including other names

RG7388 (CAS 1229705-06-9) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 100mg, 5mg, 10mM (in 1ml dmso), 50mg. Offered by: GLPBio.

brandGLPBio
catalog numberGC11594-10
cas1229705-06-9
size10mg
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Available pack sizes

brand size price
GLPBio 10mg 859.15 Pln
GLPBio 100mg 2366.27 Pln
GLPBio 5mg 709.37 Pln
GLPBio 10mM (in 1ml dmso) 817.02 Pln
GLPBio 50mg 1711.00 Pln

properties

purityNo data
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Idasanutlin is an orally available, small molecule, antagonist of MDM2 (mouse double minute 2; Mdm2 p53 binding protein homolog), with potential antineoplastic activity. Idasanutlin binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53. By preventing the MDM2-p53 interaction, p53 is not enzymatically degraded and the transcriptional activity of p53 is restored. This may lead to p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger nuclear phosphoprotein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.

Source: ChEBI

Identity
Molecular formulaC31H29Cl2F2N3O4
Molecular weight616.5 g/mol
IUPAC name4-[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid
InChIKeyTVTXCJFHQKSQQM-LJQIRTBHSA-N
SMILESCC(C)(C)C[C@H]1[C@]([C@H]([C@@H](N1)C(=O)NC2=C(C=C(C=C2)C(=O)O)OC)C3=C(C(=CC=C3)Cl)F)(C#N)C4=C(C=C(C=C4)Cl)F

Computed by PubChem (NCBI)

Synonyms: Idasanutlin, Idasanutlina, Idasanutline, idasanutlinum, Idasanutlin (RG-7388), Idasanutlin (RG7388), C31H29Cl2F2N3O4, Idasanutlin [USAN:INN], IDASANUTLIN [INN], Idasanutlin (USAN/INN)

Also listed as

Idasanutlin TRC CAS 1229705-06-9
Idasanutlin/ 99.86% (existing batch purity) TargetMol CAS 1229705-06-9
RG 7388 Biosynth CAS 1229705-06-9
Idasanutlin 98% Ambeed CAS 1229705-06-9
Idasanutlin, 99.93% MedChemExpress CAS 1229705-06-9
Idasanutlin (Standard) MedChemExpress CAS 1229705-06-9
4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid, 98%, 98% Chemat CAS 1229705-06-9
Idasanutlin, 98% Fluorochem CAS 1229705-06-9