Products 1229705-06-9

CAS 1229705-06-9 appears in our catalog under these names: Idasanutlin, RG7388, Idasanutlin/ 99.86% (existing batch purity), RG 7388, Idasanutlin 98%. Offered by: TRC, GLPBio, TargetMol, Biosynth, Ambeed. Available pack sizes: 5mg, 10mg, 100mg, 10mM (in 1ml dmso), 50mg, 2mg, 25mg, 500mg.

Idasanutlin
TRC
  • size: 5mg
  • Variants: 1
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RG7388
GLPBio
  • size: 10mg, 100mg, 5mg, 10mM (in 1ml dmso)
  • Variants: 5
from 709.37
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Idasanutlin/ 99.86% (existing batch purity)
TargetMol
  • size: 2mg, 5mg, 10mg, 25mg
  • Variants: 7
from 412.42
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RG 7388
Biosynth
  • size: 250mg, 100mg, 500mg, 1000mg
  • Variants: 4
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Idasanutlin 98%
Ambeed
  • size: 5g, 1mg, 2mg, 5mg
  • Variants: 9
from 175.69
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Idasanutlin, 99.93%
MedChemExpress
  • size: 5 mg, 100 mg, 10mM/1mL, 25 mg
  • Variants: 6
from 454.37
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Idasanutlin (Standard)
MedChemExpress
  • size: 100 mg, 5 mg, 50 mg, 10 mg
  • Variants: 5
from 1127.75
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4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid, 98%, 98%
Chemat
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 8
from 117.20
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Idasanutlin, 98%
Fluorochem
  • size: 5mg, 10mg, 50mg, 100mg
  • Variants: 6
from 200.99
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Structural formula: {0} (CAS {1})

Idasanutlin is an orally available, small molecule, antagonist of MDM2 (mouse double minute 2; Mdm2 p53 binding protein homolog), with potential antineoplastic activity. Idasanutlin binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53. By preventing the MDM2-p53 interaction, p53 is not enzymatically degraded and the transcriptional activity of p53 is restored. This may lead to p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger nuclear phosphoprotein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.

Source: ChEBI

Identity
Molecular formulaC31H29Cl2F2N3O4
Molecular weight616.5 g/mol
IUPAC name4-[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid
InChIKeyTVTXCJFHQKSQQM-LJQIRTBHSA-N
SMILESCC(C)(C)C[C@H]1[C@]([C@H]([C@@H](N1)C(=O)NC2=C(C=C(C=C2)C(=O)O)OC)C3=C(C(=CC=C3)Cl)F)(C#N)C4=C(C=C(C=C4)Cl)F

Computed by PubChem (NCBI)

Synonyms: Idasanutlin, Idasanutlina, Idasanutline, idasanutlinum, Idasanutlin (RG-7388), Idasanutlin (RG7388), C31H29Cl2F2N3O4, Idasanutlin [USAN:INN], IDASANUTLIN [INN], Idasanutlin (USAN/INN)