Products 1219810-16-8
CAS 1219810-16-8 appears in our catalog under these names: RSL3/ 99.64% (existing batch purity), RSL3, RSL3 98%, Methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methoxycarbonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate, 98%, 98%, RSL3, 99.87%. Offered by: TargetMol, GLPBio, Ambeed, Chemat, MedChemExpress. Available pack sizes: 1g, 1mg, 2mg, 5mg, 10mg, 25mg, 50mg, 100mg.
RSL3 is a beta-carboline that is 2,3,4,4a,9,9a-hexahydro-1H-beta-carboline in which the hydrogens at positions 1, 2 and 3 are replaced by 4-(methoxycarbonyl)phenyl, chloroacetyl and methoxycarbonyl groups, respectively (the 1S,2R stereoisomer). It is a potential antineoplastic agent which triggers ferroptosis by inactivating the glutathione peroxidase 4 (GPX4) enzyme. It has a role as a ferroptosis inducer, an EC 1.11.1.9 (glutathione peroxidase) inhibitor and an antineoplastic agent. It is a tertiary carboxamide, a methyl ester, a benzoate ester, an organochlorine compound, a diester and a member of beta-carbolines.
Source: ChEBI
| Molecular formula | C23H23ClN2O5 |
|---|---|
| Molecular weight | 442.9 g/mol |
| IUPAC name | methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methoxycarbonylphenyl)-1,3,4,4a,9,9a-hexahydropyrido[3,4-b]indole-3-carboxylate |
| InChIKey | CKRZDIUOUCGSBK-YBKKDXPLSA-N |
| SMILES | COC(=O)[C@H]1CC2C([C@@H](N1C(=O)CCl)C3=CC=C(C=C3)C(=O)OC)NC4=CC=CC=C24 |
Computed by PubChem (NCBI)
Synonyms:
ras-selective lethal small molecule 3