Products 923032-37-5

CAS 923032-37-5 appears in our catalog under these names: Refametinib, Refametinib/ 99.84% (existing batch purity), Refametinib 99%, N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide, 99%, 99%, Refametinib, 99.82%. Offered by: GLPBio, TargetMol, Biosynth, Ambeed, Chemat. Available pack sizes: 5mg, 1mg, 2mg, 10mg, 25mg, 50mg, 100mg, 10mM (in 1ml dmso).

Refametinib
GLPBio, Biosynth
  • size: 5mg, 10mg, 100mg, 10mM (in 1ml dmso)
  • Variants: 7
from 737.45
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Refametinib/ 99.84% (existing batch purity)
TargetMol
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 7
from 405.71
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Refametinib 99%
Ambeed
  • size: 1mg, 5mg, 10mg, 50mg
  • Variants: 6
from 175.69
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N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide, 99%, 99%
Chemat
  • size: 1mg, 5mg, 10mg, 50mg
  • Variants: 5
from 155.60
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Refametinib, 99.82%
MedChemExpress
  • size: 100 mg, 50 mg, 10mM/1mL, 5 mg
  • Variants: 5
from 477.59
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Refametinib (Standard)
MedChemExpress
  • size: 50 mg, 5 mg, 10 mg, 100 mg
  • Variants: 5
from 1559.64
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Refametinib, 99%
Fluorochem
  • size: 5mg, 10mg, 50mg, 100mg
  • Variants: 4
from 263.47
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Structural formula: {0} (CAS {1})

Refametinib is an orally bioavailable selective MEK inhibitor with potential antineoplastic activity. Refametinib specifically inhibits mitogen-activated protein kinase kinase 1 (MAP2K1 or MAPK/ERK kinase 1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

Source: ChEBI

Identity
Molecular formulaC19H20F3IN2O5S
Molecular weight572.3 g/mol
IUPAC nameN-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide
InChIKeyRDSACQWTXKSHJT-NSHDSACASA-N
SMILESCOC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)C[C@@H](CO)O)NC3=C(C=C(C=C3)I)F)F)F

Computed by PubChem (NCBI)

Synonyms: Refametinib, refametinibum, MEK Inhibitor RDEA119, Refametinib [INN], Refametinib (RDEA119, Bay 86-9766), Refametinib (RDEA119), Refamitinib, 3e8n, Refametinib; RDEA119, REFAMETINIB [WHO-DD]
Related forms of this compound
N-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-1-[(2R)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide C19H20F3IN2O5S