Products 1801747-42-1

CAS 1801747-42-1 appears in our catalog under these names: SHP099/ 98.73% (existing batch purity), SHP099, SHP099 98%, 2-Pyrazinamine, 6-(4-amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-, 98%, 98%, SHP099, 99.81%. Offered by: TargetMol, GLPBio, Biosynth, Ambeed, Chemat. Available pack sizes: 1mg, 2mg, 5mg, 10mg, 25mg, 50mg, 100mg, 10mM (in 1ml dmso).

SHP099/ 98.73% (existing batch purity)
TargetMol
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 7
from 392.86
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SHP099
GLPBio, Biosynth
  • size: 10mg, 100mg, 5mg, 10mM (in 1ml dmso)
  • Variants: 10
from 615.76
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SHP099 98%
Ambeed
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 8
from 164.56
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2-Pyrazinamine, 6-(4-amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-, 98%, 98%
Chemat
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 7
from 136.40
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SHP099, 99.81%
MedChemExpress
  • size: 10 mg, 100 mg, 50 mg, 5 mg
  • Variants: 6
from 454.37
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SHP099 (Standard)
MedChemExpress
  • size: 5 mg, 50 mg, 25 mg, 10 mg
  • Variants: 5
from 1109.17
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6-(4-AMINO-4-METHYLPIPERIDIN-1-YL)-3-(2,3-DICHLOROPHENYL)PYRAZIN-2-AMINE, 98%
Fluorochem
  • size: 5mg, 10mg, 25mg, 50mg
  • Variants: 6
from 263.47
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Structural formula: {0} (CAS {1})

SHP099 is a member of the class of pyrazines that is pyrazine substituted by amino, 2,3-dichlorophenyl, and 4-amino-4-methylpiperidin-1-yl groups at positions 2, 3, and 6, respectively. It is an allosteric SHP2 inhibitor, with IC50s of 0.690, 1.241, 0.416, 1.968, and 2.896 M for SHP2, SHP2D61Y, SHP2E69K, SHP2A72V, and SHP2E76K. It has a role as an EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor and an antineoplastic agent. It is a dichlorobenzene, an aromatic amine, a member of pyrazines and an aminopiperidine.

Source: ChEBI

Identity
Molecular formulaC16H19Cl2N5
Molecular weight352.3 g/mol
IUPAC name6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine
InChIKeyYGUFCDOEKKVKJK-UHFFFAOYSA-N
SMILESCC1(CCN(CC1)C2=CN=C(C(=N2)N)C3=C(C(=CC=C3)Cl)Cl)N

Computed by PubChem (NCBI)

Synonyms: 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine, 6-(4-Azanyl-4-Methyl-Piperidin-1-Yl)-3-[2,3-Bis(Chloranyl)phenyl]pyrazin-2-Amine, 2-Pyrazinamine, 6-(4-amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-, 6-(4-Amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-2-pyrazinamine, 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amin, orb1304056, s6388, 6-(4-amino-4-methyl-1-piperidyl)-3-(2,3-dichlorophenyl)pyrazin-2-amine
Isomers (same molecular formula)
5-(2,3-dichlorophenyl)-2-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyrimidin-4-amine C16H19Cl2N5