Products 425637-18-9

CAS 425637-18-9 appears in our catalog under these names: Sotrastaurin, Sotrastaurin/ 99.43% (existing batch purity), Sotrastaurin (AEB071), Sotrastaurin 98+%, 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione, 98+%, 98+%. Offered by: TRC, TargetMol, GLPBio, Ambeed, Chemat. Available pack sizes: 250mg, 1mg, 5mg, 10mg, 25mg, 50mg, 100mg, 500mg.

Sotrastaurin
TRC
  • size: 250mg
  • Variants: 1
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Sotrastaurin/ 99.43% (existing batch purity)
TargetMol
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 7
from 478.94
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Sotrastaurin (AEB071)
GLPBio
  • size: 10mg, 25mg, 5mg, 10mM (in 1ml dmso)
  • Variants: 5
from 812.34
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Sotrastaurin 98+%
Ambeed
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 8
from 147.88
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3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione, 98+%, 98+%
Chemat
  • size: 50mg, 250mg, 1g, 1mg
  • Variants: 8
from 122.00
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Sotrastaurin, 99.79%
MedChemExpress
  • size: 10mM/1mL, 50 mg, 10 mg, 5 mg
  • Variants: 6
from 751.58
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Sotrastaurin (Standard)
MedChemExpress
  • size: 1 mg, 10 mg, 50 mg, 100 mg
  • Variants: 6
from 886.26
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3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione, 98+%
Fluorochem
  • size: 5mg, 10mg, 25mg, 50mg
  • Variants: 7
from 227.02
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Structural formula: {0} (CAS {1})

Sotrastaurin is a member of the class of maleimides that is maleimide which is substituted at position 3 by an indol-3-yl group and at position 4 by a quinazolin-4-yl group, which in turn is substituted at position 2 by a 4-methylpiperazin-1-yl group. It is a potent and selective inhibitor of protein kinase C and has been investigated as an immunosuppresant in renal transplant patients. It has a role as an anticoronaviral agent, an immunosuppressive agent and an EC 2.7.11.13 (protein kinase C) inhibitor. It is a member of indoles, a member of quinazolines, a N-alkylpiperazine, a N-arylpiperazine and a member of maleimides.

Source: ChEBI

Identity
Molecular formulaC25H22N6O2
Molecular weight438.5 g/mol
IUPAC name3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione
InChIKeyOAVGBZOFDPFGPJ-UHFFFAOYSA-N
SMILESCN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65

Computed by PubChem (NCBI)

Synonyms: Sotrastaurin, sotrastaurina, sotrastaurine, sotrastaurinum, 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)pyrrole-2,5-dione, Sotrastaurin (AEB071), Sotrastaurin [USAN], SOTRASTAURIN [WHO-DD], Sotrastaurin [USAN:INN]