TAK 632

cas: 1228591-30-7 — see every product listed under this CAS number, including other names

TAK 632 (CAS 1228591-30-7) is a chemical reagent available from Chemat. Available pack sizes: 50mg, 10mg. Offered by: Biosynth.

brandBiosynth
catalog numberFC103614-50mg
cas1228591-30-7
size50mg
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Available pack sizes

brand size price
Biosynth 50mg price on request
Biosynth 10mg price on request

properties

categoryLife Sciences
sub-category 1Ligands
sub-category 2Enzyme Modulators
purityNo data
delivery time1-2 weeks
Structural formula: {0} (CAS {1})

TAK-632 is a member of the class of benzothiazoles that is 1,3-benzothiazole substituted by (cyclopropanecarbonyl)amino, 4-fluoro-3-{2-[3-(trifluoromethyl)phenyl]acetamido}phenoxy, and cyano groups at positions 2, 6 and 7, respectively. It is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAFV600E, BRAFWT, respectively. It has a role as a necroptosis inhibitor, an antineoplastic agent, an apoptosis inducer, a B-Raf inhibitor and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a secondary carboxamide, a nitrile, an aromatic ether, a member of benzothiazoles, a cyclopropylcarboxamide, a member of (trifluoromethyl)benzenes and a member of monofluorobenzenes.

Source: ChEBI

Identity
Molecular formulaC27H18F4N4O3S
Molecular weight554.5 g/mol
IUPAC nameN-[7-cyano-6-[4-fluoro-3-[[2-[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide
InChIKeyOJFKUJDRGJSAQB-UHFFFAOYSA-N
SMILESC1CC1C(=O)NC2=NC3=C(S2)C(=C(C=C3)OC4=CC(=C(C=C4)F)NC(=O)CC5=CC(=CC=C5)C(F)(F)F)C#N

Computed by PubChem (NCBI)

Synonyms: 4ksp, orb1226736, orb1307266, s7291, compound 8B [PMID: 23906342]

Also listed as

N-[7-cyano-6-(4-fluoro-3-{2-[3-(trifluoromethyl)phenyl]acetamido}phenoxy)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide, 95% Combi-blocks CAS 1228591-30-7
TAK-632/ 98.92% (existing batch purity) TargetMol CAS 1228591-30-7
TAK–632 GLPBio CAS 1228591-30-7
TAK-632 Chemat CAS 1228591-30-7
TAK-632 98% Ambeed CAS 1228591-30-7
TAK-632, 99.02% MedChemExpress CAS 1228591-30-7
N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide, 98%, 98% Chemat CAS 1228591-30-7
Benzeneacetamide, N-[5-[[7-cyano-2-[(cyclopropylcarbonyl)amino]-6-benzothiazolyl]oxy]-2-fluorophenyl]-3-(trifluoromethyl)-, 98% Fluorochem CAS 1228591-30-7