TAK–632
cas: 1228591-30-7 — see every product listed under this CAS number, including other names
TAK–632 (CAS 1228591-30-7) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 100mg, 5mg, 10mM (in 1ml dmso), 50mg. Offered by: GLPBio.
| brand | GLPBio |
|---|---|
| catalog number | GC17455-10 |
| cas | 1228591-30-7 |
| size | 10mg |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| GLPBio | 10mg | 788.94 Pln | |
| GLPBio | 100mg | 1912.26 Pln | |
| GLPBio | 5mg | 667.25 Pln | |
| GLPBio | 10mM (in 1ml dmso) | 685.97 Pln | |
| GLPBio | 50mg | 1444.21 Pln |
properties
| purity | No data |
|---|---|
| delivery time | To be confirmed by Chemat |
TAK-632 is a member of the class of benzothiazoles that is 1,3-benzothiazole substituted by (cyclopropanecarbonyl)amino, 4-fluoro-3-{2-[3-(trifluoromethyl)phenyl]acetamido}phenoxy, and cyano groups at positions 2, 6 and 7, respectively. It is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAFV600E, BRAFWT, respectively. It has a role as a necroptosis inhibitor, an antineoplastic agent, an apoptosis inducer, a B-Raf inhibitor and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a secondary carboxamide, a nitrile, an aromatic ether, a member of benzothiazoles, a cyclopropylcarboxamide, a member of (trifluoromethyl)benzenes and a member of monofluorobenzenes.
Source: ChEBI
| Molecular formula | C27H18F4N4O3S |
|---|---|
| Molecular weight | 554.5 g/mol |
| IUPAC name | N-[7-cyano-6-[4-fluoro-3-[[2-[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide |
| InChIKey | OJFKUJDRGJSAQB-UHFFFAOYSA-N |
| SMILES | C1CC1C(=O)NC2=NC3=C(S2)C(=C(C=C3)OC4=CC(=C(C=C4)F)NC(=O)CC5=CC(=CC=C5)C(F)(F)F)C#N |
Computed by PubChem (NCBI)