TW–37

cas: 877877-35-5 — see every product listed under this CAS number, including other names

TW–37 (CAS 877877-35-5) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 10mM (in 1ml dmso), 50mg. Offered by: GLPBio.

brandGLPBio
catalog numberGC12649-10
cas877877-35-5
size10mg
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Available pack sizes

brand size price
GLPBio 10mg 793.62 Pln
GLPBio 10mM (in 1ml dmso) 831.06 Pln
GLPBio 50mg 1888.86 Pln

properties

purityNo data
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

TW-37 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 2,3,4-trihydroxy-5-[2-(propan-2-yl)benzyl]benzoic acid with the amino group of 4-[(2-tert-butylphenyl)sulfonyl]aniline. It is a potent inhibitor of Bcl-2 family of proteins (Ki = 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL). It has a role as a radiosensitizing agent, a B-cell lymphoma 2 inhibitor, an antineoplastic agent, an angiogenesis inhibitor and an apoptosis inducer. It is a secondary carboxamide, a member of benzamides, a benzenetriol and a sulfone.

Source: ChEBI

Identity
Molecular formulaC33H35NO6S
Molecular weight573.7 g/mol
IUPAC nameN-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide
InChIKeyPQAPVTKIEGUPRN-UHFFFAOYSA-N
SMILESCC(C)C1=CC=CC=C1CC2=CC(=C(C(=C2O)O)O)C(=O)NC3=CC=C(C=C3)S(=O)(=O)C4=CC=CC=C4C(C)(C)C

Computed by PubChem (NCBI)

Synonyms: tw 37, tw-37?, orb1223766, orb1300906, s1121

Also listed as

N-{4-[(2-tert-butylbenzene)sulfonyl]phenyl}-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide, 95% Combi-blocks CAS 877877-35-5
TW-37/ 98% TargetMol CAS 877877-35-5
TW-37 98% Ambeed CAS 877877-35-5
N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide, 98%, 98% Chemat CAS 877877-35-5
TW-37, 99.50% MedChemExpress CAS 877877-35-5