Products 877877-35-5

CAS 877877-35-5 appears in our catalog under these names: N-{4-[(2-tert-butylbenzene)sulfonyl]phenyl}-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide, 95%, TW–37, TW-37/ 98%, TW-37 98%, N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide, 98%, 98%. Offered by: Combi-blocks, GLPBio, TargetMol, Ambeed, Chemat. Available pack sizes: 250mg, 100mg, 10mg, 10mM (in 1ml dmso), 50mg, 1mg, 2mg, 5mg.

N-{4-[(2-tert-butylbenzene)sulfonyl]phenyl}-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide, 95%
Combi-blocks
  • size: 250mg, 100mg
  • Variants: 2
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TW–37
GLPBio
  • size: 10mg, 10mM (in 1ml dmso), 50mg
  • Variants: 3
from 793.62
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TW-37/ 98%
TargetMol
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 7
from 412.42
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TW-37 98%
Ambeed
  • size: 10mg, 50mg, 100mg, 250mg
  • Variants: 4
from 681.88
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N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide, 98%, 98%
Chemat
  • size: 10mg, 50mg, 100mg
  • Variants: 3
from 597.20
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TW-37, 99.50%
MedChemExpress
  • size: 5 mg, 10mM/1mL, 10 mg, 50 mg
  • Variants: 4
from 598.33
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Structural formula: {0} (CAS {1})

TW-37 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 2,3,4-trihydroxy-5-[2-(propan-2-yl)benzyl]benzoic acid with the amino group of 4-[(2-tert-butylphenyl)sulfonyl]aniline. It is a potent inhibitor of Bcl-2 family of proteins (Ki = 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL). It has a role as a radiosensitizing agent, a B-cell lymphoma 2 inhibitor, an antineoplastic agent, an angiogenesis inhibitor and an apoptosis inducer. It is a secondary carboxamide, a member of benzamides, a benzenetriol and a sulfone.

Source: ChEBI

Identity
Molecular formulaC33H35NO6S
Molecular weight573.7 g/mol
IUPAC nameN-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide
InChIKeyPQAPVTKIEGUPRN-UHFFFAOYSA-N
SMILESCC(C)C1=CC=CC=C1CC2=CC(=C(C(=C2O)O)O)C(=O)NC3=CC=C(C=C3)S(=O)(=O)C4=CC=CC=C4C(C)(C)C

Computed by PubChem (NCBI)

Synonyms: tw 37, tw-37?, orb1223766, orb1300906, s1121