TW-37, 99.50%
cas: 877877-35-5 — see every product listed under this CAS number, including other names
TW-37, 99.50% (CAS 877877-35-5) is a chemical reagent available from Chemat. Available pack sizes: 5 mg, 10mM/1mL, 10 mg, 50 mg. Offered by: MedChemExpress.
| brand | MedChemExpress |
|---|---|
| catalog number | HY-12020-5 mg |
| cas | 877877-35-5 |
| size | 5 mg |
| availability | In stock |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| MedChemExpress | 5 mg | 598.33 Pln | |
| MedChemExpress | 10mM/1mL | 723.72 Pln | |
| MedChemExpress | 10 mg | 886.26 Pln | |
| MedChemExpress | 50 mg | 2279.46 Pln |
properties
| delivery time | 1-2 weeks |
|---|---|
| purity | 99.50% |
TW-37 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 2,3,4-trihydroxy-5-[2-(propan-2-yl)benzyl]benzoic acid with the amino group of 4-[(2-tert-butylphenyl)sulfonyl]aniline. It is a potent inhibitor of Bcl-2 family of proteins (Ki = 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL). It has a role as a radiosensitizing agent, a B-cell lymphoma 2 inhibitor, an antineoplastic agent, an angiogenesis inhibitor and an apoptosis inducer. It is a secondary carboxamide, a member of benzamides, a benzenetriol and a sulfone.
Source: ChEBI
| Molecular formula | C33H35NO6S |
|---|---|
| Molecular weight | 573.7 g/mol |
| IUPAC name | N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide |
| InChIKey | PQAPVTKIEGUPRN-UHFFFAOYSA-N |
| SMILES | CC(C)C1=CC=CC=C1CC2=CC(=C(C(=C2O)O)O)C(=O)NC3=CC=C(C=C3)S(=O)(=O)C4=CC=CC=C4C(C)(C)C |
Computed by PubChem (NCBI)