Tolebrutinib

cas: 1971920-73-6 — see every product listed under this CAS number, including other names

Tolebrutinib (CAS 1971920-73-6) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 100mg, 5mg, 50mg, 25mg. Offered by: GLPBio, Biosynth.

brandGLPBio
catalog numberGC63232-10
cas1971920-73-6
size10mg
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Available pack sizes

brand size price
GLPBio 10mg 2647.10 Pln
GLPBio 100mg 10945.63 Pln
GLPBio 5mg 1888.86 Pln
GLPBio 50mg 7491.42 Pln
Biosynth 25mg price on request
Biosynth 10mg price on request

properties

purityNo data
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Tolebrutinib (SAR442168) is a potent, selective, orally active and brain-penetrant inhibitor of Bruton tyrosine kinase (BTK), with IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively. Tolebrutinib exhibits efficacy in central nervous system immunity. Tolebrutinib can be used for the research of multiple sclerosis (MS).

Source: ChEBI

Identity
Molecular formulaC26H25N5O3
Molecular weight455.5 g/mol
IUPAC name4-amino-3-(4-phenoxyphenyl)-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]imidazo[4,5-c]pyridin-2-one
InChIKeyKOEUOFPEZFUWRF-LJQANCHMSA-N
SMILESC=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=NC=C3)N)N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5

Computed by PubChem (NCBI)

Synonyms: Tolebrutinib, Tolebrutinib [INN], Tolebrutinib [USAN], TOLEBRUTINIB [WHO-DD], example 3 [WO2016196840A1], example 3 (WO2016196840A1), BTK Inhibitor SAR442168, Bruton's Tyrosine Kinase Inhibitor SAR442168, c]pyridin-2-one, Cenrifki
Isomers (same molecular formula)
5-[4-[4-(5-cyano-1H-indol-3-yl)-4-oxobutyl]piperazin-1-yl]-1-benzofuran-2-carboxamide C26H25N5O3
4-[3-[[(2S)-2-(6-methoxy-3-pyridinyl)-2,3-dihydro-1,4-benzodioxin-6-yl]methyl]imidazo[4,5-b]pyridin-6-yl]-2-methylbut-3-yn-2-amine C26H25N5O3
(2S)-N-[4-[3-cyano-1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]indol-5-yl]oxyphenyl]pyrrolidine-2-carboxamide C26H25N5O3
4-[3-[[2-(6-methoxy-3-pyridinyl)-2,3-dihydro-1,4-benzodioxin-6-yl]methyl]imidazo[4,5-b]pyridin-6-yl]-2-methylbut-3-yn-2-amine C26H25N5O3

Also listed as

Tolebrutinib/ 99.2% (existing batch purity) TargetMol CAS 1971920-73-6
Tolebrutinib, 99.79% MedChemExpress CAS 1971920-73-6
Tolebrutinib, 97% Ambeed CAS 1971920-73-6
(R)-1-(1-Acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one, 97% BLDpharm CAS 1971920-73-6
(R)-1-(1-Acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one, 98% Chemat CAS 1971920-73-6