Vargatef

cas: 1160294-26-7 — see every product listed under this CAS number, including other names

Vargatef (CAS 1160294-26-7) is a chemical reagent available from Chemat. Available pack sizes: 250mg, 100mg, 500mg. Offered by: Biosynth.

brandBiosynth
catalog numberKWB29426-250mg
cas1160294-26-7
size250mg
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Available pack sizes

brand size price
Biosynth 250mg price on request
Biosynth 100mg price on request
Biosynth 500mg price on request

properties

categoryLife Sciences
purityNo data
delivery time1-2 weeks
Structural formula: {0} (CAS {1})

Nintedanib is a member of the class of oxindoles that is a kinase inhibitor used (in the form of its ethylsulfonate salt) for the treatment of idiopathic pulmonary fibrosis and cancer. It has a role as an antifibrotic agent, an antineoplastic agent, a tyrosine kinase inhibitor, an angiogenesis inhibitor, a fibroblast growth factor receptor antagonist and a vascular endothelial growth factor receptor antagonist. It is a methyl ester, an aromatic amine, a member of oxindoles, a N-alkylpiperazine, an enamine, an aromatic ester and an aromatic amide. It is a conjugate base of a nintedanib(1+).

Source: ChEBI

Identity
Molecular formulaC31H33N5O4
Molecular weight539.6 g/mol
IUPAC namemethyl 2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate
InChIKeyCPMDPSXJELVGJG-UHFFFAOYSA-N
SMILESCN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O

Computed by PubChem (NCBI)

Synonyms: Nintedanib, Vargatef, Intedanib, Nintedanib (BIBF 1120), Nintedanib D3, Ofev (TN), Nintedanib [INN], Nintedanib E-isomer, Nintedanib [USAN], Nintedanib [USAN:INN]
Related forms of this compound
methyl 2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate C31H33N5O4
methyl 2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate C31H33N5O4
methyl 2-hydroxy-3-[N-[4-[methyl-[2-(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate C31H33N5O4
methyl 2-hydroxy-3-[N-[4-[methyl-[2-[4-(trideuteriomethyl)piperazin-1-yl]acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate C31H33N5O4
Isomers (same molecular formula)
(4R)-2-(4-methylphenyl)-3-[6-[(4R)-2-(4-methylphenyl)-4-oxido-1-oxo-5,6,7,7a-tetrahydro-3H-pyrrolo[1,2-c]imidazol-4-ium-3-yl]-2-pyridinyl]-4-oxido-5,6,7,7a-tetrahydro-3H-pyrrolo[1,2-c]imidazol-4-ium-1-one C31H33N5O4
(4R)-2-(2-methylphenyl)-3-[6-[(4R)-2-(2-methylphenyl)-4-oxido-1-oxo-5,6,7,7a-tetrahydro-3H-pyrrolo[1,2-c]imidazol-4-ium-3-yl]-2-pyridinyl]-4-oxido-5,6,7,7a-tetrahydro-3H-pyrrolo[1,2-c]imidazol-4-ium-1-one C31H33N5O4

Also listed as

Vargatef, 95% Combi-blocks CAS 1160294-26-7