Products 1088965-37-0
CAS 1088965-37-0 appears in our catalog under these names: GSK 923295, >95% (HPLC), GSK-923295/ 99.71% (existing batch purity), GSK–923295, GSK 923295, GSK-923295 98%. Offered by: TRC, TargetMol, GLPBio, Biosynth, Ambeed. Available pack sizes: 50mg, 5mg, 1mg, 2mg, 10mg, 25mg, 100mg, 10mM (in 1ml dmso).
GSK-923295 is an imidazopyridine that is imidazo[1,2-a]pyridine substituted by 4-{(2S)-2-[3-chloro-4-(propan-2-yloxy)benzamido]-3-[(N,N-dimethylglycyl)amino]propyl}phenyl, and (1S)-1-hydroxyethyl groups at positions 2 and 8, respectively. It is an allosteric inhibitor of centromere-associated protein-E (CENP-E) kinesin motor ATPase activity (Ki = 3.2 nM and 1.6 nM for human and canine CENP-E motordomains, respectively). It has a role as a centromere protein E inhibitor, an antineoplastic agent and an antimitotic. It is a secondary carboxamide, a member of benzamides, an aromatic ether, a secondary alcohol, an imidazopyridine, a tertiary amino compound and a member of monochlorobenzenes.
Source: ChEBI
| Molecular formula | C32H38ClN5O4 |
|---|---|
| Molecular weight | 592.1 g/mol |
| IUPAC name | 3-chloro-N-[(2S)-1-[[2-(dimethylamino)acetyl]amino]-3-[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]propan-2-yl]-4-propan-2-yloxybenzamide |
| InChIKey | WHMXDBPHBVLYRC-OFVILXPXSA-N |
| SMILES | C[C@@H](C1=CC=CN2C1=NC(=C2)C3=CC=C(C=C3)C[C@@H](CNC(=O)CN(C)C)NC(=O)C4=CC(=C(C=C4)OC(C)C)Cl)O |
Computed by PubChem (NCBI)