CAS 1092364-38-9 appears in our catalog under these names: Poziotinib, >95% (HPLC), Poziotinib/ 97.81% (existing batch purity), Poziotinib, Poziotinib 98%, 1-[4-[[4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-propen-1-one, 98%, 98%. Offered by: TRC, TargetMol, GLPBio, Biosynth, Ambeed. Available pack sizes: 10mg, 1mg, 5mg, 25mg, 50mg, 100mg, 250mg, 1g.
Poziotinib is a member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, [1-(prop-2-enoyl)piperidin-4-yl]oxy, and methoxy groups at positions 4, 6, and 7, respectively. It is a potent and irreversible tyrosine kinase inhibitor targeting EGFR and HER2 with exon 20 insertion mutations. It has a role as an antineoplastic agent, an apoptosis inducer and an epidermal growth factor receptor antagonist. It is a member of acrylamides, a dichlorobenzene, an aromatic ether, a member of quinazolines, a diether, a N-acylpiperidine, a substituted aniline, a secondary amino compound and a member of monofluorobenzenes.
Source: ChEBI
| Molecular formula | C23H21Cl2FN4O3 |
|---|---|
| Molecular weight | 491.3 g/mol |
| IUPAC name | 1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one |
| InChIKey | LPFWVDIFUFFKJU-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C |
Computed by PubChem (NCBI)