Products 1110813-31-4

CAS 1110813-31-4 appears in our catalog under these names: (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide, 99%, 99%, Dacomitinib, Dacomitinib, >95% (HPLC), Dacomitinib/ 100%, Dacomitinib (PF299804, PF299). Offered by: Chemat, Chemat Brand, TRC, TargetMol, GLPBio. Available pack sizes: 5mg, 10mg, 100mg, 250mg, 1g, 5g, 10g, on request.

(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide, 99%, 99%
Chemat
  • size: 5mg, 10mg, 100mg, 250mg
  • Variants: 7
from 126.80
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Dacomitinib
Chemat Brand, Biosynth
  • size: on request, 50mg, 10mg
  • Variants: 3
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Dacomitinib, >95% (HPLC)
TRC
  • size: 10mg, 50mg, 5mg
  • Variants: 3
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Dacomitinib/ 100%
TargetMol
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 9
from 399.00
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Dacomitinib (PF299804, PF299)
GLPBio
  • size: 25mg, 5mg, 10mM (in 1ml dmso)
  • Variants: 3
from 779.58
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Dacomitinib, 97%
Thermo Scientific (Acros)
  • size: 100MG
  • Variants: 1
from 913.16
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Dacomitinib 98%
Ambeed
  • size: 10g, 1mg, 100mg, 250mg
  • Variants: 6
from 159.00
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Dacomitinib, 99.74%
MedChemExpress
  • size: 50 mg, 5 mg, 100 mg, 10mM/1mL
  • Variants: 6
from 561.18
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Dacomitinib (Standard)
MedChemExpress
  • size: 50 mg, 10 mg, 5 mg, 25 mg
  • Variants: 5
from 1081.31
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Structural formula: {0} (CAS {1})

Dacomitinib is a member of the class of quinazolines that is 7-methoxyquinazoline-4,6-diamine in which the amino group at position 4 is substituted by a 3-chloro-4-fluorophenyl group and the amino group at position 6 is substituted by an (E)-4-(piperidin-1-yl)but-2-enoyl group. It has a role as an antineoplastic agent and an epidermal growth factor receptor antagonist. It is a secondary carboxamide, a member of piperidines, a member of quinazolines, a secondary amino compound, a tertiary amino compound, an enamide, a member of monochlorobenzenes and a member of monofluorobenzenes.

Source: ChEBI

Identity
Molecular formulaC24H25ClFN5O2
Molecular weight469.9 g/mol
IUPAC name(E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide
InChIKeyLVXJQMNHJWSHET-AATRIKPKSA-N
SMILESCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)/C=C/CN4CCCCC4

Computed by PubChem (NCBI)

Synonyms: Dacomitinib, Dacomitinib anhydrous, dacomitinibum, Vizimpro, pf00299804, EGFR Inhibitor PF-00299804, Dacomitinib (PF299804, PF299), Dacomitinib (PF299804), Dacomitinib [USAN:INN], Dacomitinib (INN)
Related forms of this compound
(E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide C24H25ClFN5O2
Isomers (same molecular formula)
(E)-N-[4-(4-chloro-3-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide C24H25ClFN5O2