Products 127-33-3

CAS 127-33-3 appears in our catalog under these names: Chlortetracycline EP Impurity B,Demeclocycline, Demeclocycline, Demeclocycline/ 97.46% (existing batch purity), (4S,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide, 98%, 98%, Demeclocycline, 98.0%. Offered by: Chemat Brand, GLPBio, TargetMol, Biosynth, Chemat. Available pack sizes: on request, 5mg, 1mg, 10mg, 25mg, 50mg, 100mg, 200mg.

Chlortetracycline EP Impurity B,Demeclocycline
Chemat Brand
  • size: on request
  • Variants: 1
View product
Demeclocycline
GLPBio, Biosynth
  • size: 5mg, 25mg, 10mg, 50mg
  • Variants: 5
from 877.87
View product
Demeclocycline/ 97.46% (existing batch purity)
TargetMol
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 5
from 439.25
View product
(4S,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide, 98%, 98%
Chemat
  • size: 25mg, 50mg, 100mg, 200mg
  • Variants: 6
from 770.00
View product
Demeclocycline, 98.0%
MedChemExpress
  • size: 25 mg, 50 mg, 10 mg, 10mM/1mL
  • Variants: 6
from 649.42
View product
Demeclocycline (Standard)
MedChemExpress
  • size: 25 mg, 10 mg, 50 mg, 100 mg
  • Variants: 5
from 1197.41
View product
(4S,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide, 98%
Chemat
  • size: 1mg
  • Variants: 1
from 390.80
View product
Structural formula: {0} (CAS {1})

Demeclocycline is tetracycline which lacks the methyl substituent at position 7 and in which the hydrogen para- to the phenolic hydroxy group is substituted by chlorine. Like tetracycline, it is an antibiotic, but being excreted more slowly, effective blood levels are maintained for longer. It is used (mainly as the hydrochloride) for the treatment of Lyme disease, acne and bronchitis, as well as for hyponatraemia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective. It has a role as a geroprotector, an aquaretic and an antibacterial drug.

Source: ChEBI

Identity
Molecular formulaC21H21ClN2O8
Molecular weight464.9 g/mol
IUPAC name(4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
InChIKeyGUXHBMASAHGULD-SEYHBJAFSA-N
SMILESCN(C)[C@H]1[C@@H]2C[C@@H]3[C@@H](C4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O

Computed by PubChem (NCBI)

Synonyms: demeclocycline, Demethylchlortetracycline, DMCT, Ledermycin, 6-Demethyl-7-chlorotetracycline, Demethylchlortetracyclin, Demeclociclina, 7-Chloro-6-demethyltetracycline, Demeclocyclinum, Clortetrin
Related forms of this compound
(4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide C21H21ClN2O8
(4R,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide C21H21ClN2O8