Products 1353564-66-5

CAS 1353564-66-5 is the registry number for NP-12. Offered by: Creative Peptides. Available pack sizes: on request.

NP-12
Creative Peptides
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  • Variants: 1
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Structural formula: {0} (CAS {1})

Tideglusib is a member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy. It has a role as a neuroprotective agent, an anti-inflammatory agent, an apoptosis inducer and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a member of benzenes, a member of naphthalenes and a thiadiazolidine.

Source: ChEBI

Identity
Molecular formulaC19H14N2O2S
Molecular weight334.4 g/mol
IUPAC name4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione
InChIKeyPMJIHLSCWIDGMD-UHFFFAOYSA-N
SMILESC1=CC=C(C=C1)CN2C(=O)N(SC2=O)C3=CC=CC4=CC=CC=C43

Computed by PubChem (NCBI)

Synonyms: Tideglusib, 4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione, tideglusibum, Zentylor, Nypta, Zentylor nypta, 4-benzyl-2-(a-naphtyl)-1,2,4-thiadiazolidine-3,5-dione, 4-benzyl-2-(naphthalene-1-yl)-1,2,4-thiadiazolidine-3,5-dione, Tideglusib [INN], Tideglusib(NP-031112)
Isomers (same molecular formula)
2-(2,5-dioxopyrrol-1-yl)-6-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile C19H14N2O2S