Products 136572-09-3
CAS 136572-09-3 appears in our catalog under these names: Irinotecan hydrochloride trihydrate, min. 95 %, 25 g, Irinotecan hydrochloride trihydrate, 98%, Irinotecan Hydrochloride Trihydrate, >95% (HPLC), Irinotecan Hydrochloride Trihydrate, Irinotecan hydrochloride trihydrate/ 99.52% (existing batch purity). Offered by: Roth, Combi-blocks, TRC, Mikromol, LoGiCal. Available pack sizes: 25g, 5g, 1g, 250mg, 100mg, 25mg, 50mg, 10mg.
Irinotecan hydrochloride hydrate is a hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active. It has a role as an antineoplastic agent, a prodrug, an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an apoptosis inducer. It contains an irinotecan hydrochloride (anhydrous).
Source: ChEBI
| Molecular formula | C33H45ClN4O9 |
|---|---|
| Molecular weight | 677.2 g/mol |
| IUPAC name | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;trihydrate;hydrochloride |
| InChIKey | KLEAIHJJLUAXIQ-JDRGBKBRSA-N |
| SMILES | CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.O.O.O.Cl |
Computed by PubChem (NCBI)