Products 1369665-02-0

CAS 1369665-02-0 appears in our catalog under these names: Cobimetinib hemifumarate, Cobimetinib fumarate, Cobimetinib (hemifumarate), 99.68%, Cobimetinib (hemifumarate). Offered by: TargetMol, Biosynth, MedChemExpress, Chemat. Available pack sizes: 2mg, 50mg, 10mg, 2000mg, 100 mg, 10 mg, 50 mg, 5 mg.

Cobimetinib hemifumarate
TargetMol
  • size: 2mg
  • Variants: 1
from 532.05
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Cobimetinib fumarate
Biosynth
  • size: 50mg, 10mg, 2000mg
  • Variants: 3
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Cobimetinib (hemifumarate), 99.68%
MedChemExpress
  • size: 100 mg, 10 mg, 50 mg, 5 mg
  • Variants: 5
from 579.76
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Cobimetinib (hemifumarate)
Chemat
  • size: 2mg, 5mg, 50mg
  • Variants: 3
from 328.40
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Structural formula: {0} (CAS {1})

Cobimetinib fumarate is a fumarate salt prepared from cobimetinib by reaction of one molecule of fumaric acid for every two molecules of cobimetinib. An inhibitor of mitogen-activated protein kinase that is used in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma. It has a role as an antineoplastic agent and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is an organoammonium salt and a fumarate salt. It contains a cobimetinib(1+).

Source: ChEBI

Identity
Molecular formulaC46H46F6I2N6O8
Molecular weight1178.7 g/mol
IUPAC name(E)-but-2-enedioic acid;bis([3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl]methanone)
InChIKeyRESIMIUSNACMNW-BXRWSSRYSA-N
SMILESC1CCN[C@@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O.C1CCN[C@@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O.C(=C/C(=O)O)\C(=O)O

Computed by PubChem (NCBI)

Synonyms: Cobimetinib Fumarate, Cobimetinib hemifumarate, Xl-518 hemifumarate, Cobimetinib fumarate [USAN], Cobimetinib fumarate (USAN), Cobimetinib fumarate - Bio-X, Cotellic (TN), orb1685865, COBIMETINIB FUMARATE [MI], COBIMETINIB FUMARATE [JAN]