Products 1449685-96-4
CAS 1449685-96-4 appears in our catalog under these names: 4-((4-Ethylpiperazin-1-yl)methyl)-N-(4-methyl-3-((2-oxoindolin-5-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide, 99%, Ddr1-In-1/ 99.34% (existing batch purity), DDR1–IN–1, DDR1-IN-1 dihydrochloride, DDR1-IN-1, 98.20%. Offered by: Chemat, TargetMol, GLPBio, Biosynth, MedChemExpress. Available pack sizes: 1mg, 5mg, 10mg, 25mg, 50mg, 2mg, 100mg, 10mM (in 1ml dmso).
DDR1-IN-1 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoic acid with the amino group of 5-(5-amino-2-methylphenoxy)-1,3-dihydro-2H-indol-2-one. It is a potent inhibitor of discoidin domain receptor tyrosine kinase 1 and 2 (DDR1/2) with IC50 = 105 nM and 413 nM, respectively. It has a role as an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a secondary carboxamide, a member of benzamides, an aromatic ether, a member of oxindoles, a N-alkylpiperazine and a member of (trifluoromethyl)benzenes.
Source: ChEBI
| Molecular formula | C30H31F3N4O3 |
|---|---|
| Molecular weight | 552.6 g/mol |
| IUPAC name | 4-[(4-ethylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(2-oxo-1,3-dihydroindol-5-yl)oxy]phenyl]-3-(trifluoromethyl)benzamide |
| InChIKey | AOZPVMOOEJAZGK-UHFFFAOYSA-N |
| SMILES | CCN1CCN(CC1)CC2=C(C=C(C=C2)C(=O)NC3=CC(=C(C=C3)C)OC4=CC5=C(C=C4)NC(=O)C5)C(F)(F)F |
Computed by PubChem (NCBI)