CAS 156897-06-2 appears in our catalog under these names: Licofelone, 95%, Licofelone, >95% (HPLC), Licofelone/ 99.49% (existing batch purity), Licofelone, Licofelone, >95.0%(HPLC). Offered by: Combi-blocks, TRC, TargetMol, GLPBio, Biosynth. Available pack sizes: 10mg, 1mg, 5mg, 25mg, 50mg, 100mg, 200mg, 10mM (in 1ml dmso).
Licofelone is a member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine substituted by methyl, methyl, carboxymethyl, 4-chlorophenyl, and phenyl groups at positions 2, 2, 5, 6, and 7, respectively. It is a dual inhibitor of cyclooxygenase isoforms and 5-lipoxygenase and is under development for treatment of osteoarthritis. It has a role as a non-steroidal anti-inflammatory drug, an analgesic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antineoplastic agent, an anticonvulsant, a neuroprotective agent and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a monocarboxylic acid, a member of pyrrolizines and a member of monochlorobenzenes.
Source: ChEBI
| Molecular formula | C23H22ClNO2 |
|---|---|
| Molecular weight | 379.9 g/mol |
| IUPAC name | 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid |
| InChIKey | UAWXGRJVZSAUSZ-UHFFFAOYSA-N |
| SMILES | CC1(CC2=C(C(=C(N2C1)CC(=O)O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C |
Computed by PubChem (NCBI)