Products 163133-43-5
CAS 163133-43-5 appears in our catalog under these names: Naproxcinod, 97%, 97%, Naproxcinod. Offered by: Chemat, MedChemExpress. Available pack sizes: 5mg, Get quote.
Naproxcinod is a carboxylic ester obtained by formal condensation of the carboxy group of naproxen with the hydroxy group of 4-(nitrooxy)butanol. A cyclooxygenase-inhibiting nitric oxide donator that is metabolised to naproxen and a nitric oxide donating moiety, effective in treatment of osteoarthritis. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a prodrug and a nitric oxide donor. It is a carboxylic ester, a methoxynaphthalene and a nitrate ester. It is functionally related to a butane-1,4-diol and a naproxen.
Source: ChEBI
| Molecular formula | C18H21NO6 |
|---|---|
| Molecular weight | 347.4 g/mol |
| IUPAC name | 4-nitrooxybutyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate |
| InChIKey | AKFJWRDCWYYTIG-ZDUSSCGKSA-N |
| SMILES | C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)OCCCCO[N+](=O)[O-] |
Computed by PubChem (NCBI)
Synonyms:
Naproxcinod, Nitronaproxen, naproxen-n-butyl nitrate, NO-naproxen, naproxcinodum, 4-(Nitrooxy)butyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate, (S)-2-(6-Methoxy-2-naphthyl)propanoic acid 4-nitrooxybutyl ester, 4-nitrooxybutyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate, NicOx, nitric oxide naproxen