Products 174022-42-5
CAS 174022-42-5 appears in our catalog under these names: Bevirimat, min. 95 %, 5 mg, Bevirimat, >95% (HPLC), Bevirimat/ 99.58% (existing batch purity), Bevirimat, bevirimat, 99%, 99%. Offered by: Roth, TRC, TargetMol, Biosynth, Chemat. Available pack sizes: 5mg, 2,5mg, 25mg, 1mg, 10mg, 50mg, 100mg, 2mg.
Bevirimat is a pentacyclic triterpenoid obtained by the formal condensation of 2,2-dimethylsuccinic acid with the 3-hydroxy group of betulinic acid. It is isolated from the Chinese herb Syzygium claviflorum. The first in the class of HIV-1 maturation inhibitors to be studied in humans, bevirimat was identified as a potent HIV drug candidate and several clinical trials were conducted, but development into a new drug was plagued by numerous resistance-related problems. It has a role as a metabolite and a HIV-1 maturation inhibitor. It is a monocarboxylic acid, a pentacyclic triterpenoid and a dicarboxylic acid monoester. It is functionally related to a betulinic acid.
Source: ChEBI
| Molecular formula | C36H56O6 |
|---|---|
| Molecular weight | 584.8 g/mol |
| IUPAC name | (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-(3-carboxy-3-methylbutanoyl)oxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid |
| InChIKey | YJEJKUQEXFSVCJ-WRFMNRASSA-N |
| SMILES | CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)OC(=O)CC(C)(C)C(=O)O)C)C(=O)O |
Computed by PubChem (NCBI)
Synonyms:
Bevirimat, bevirimatum, 3-O-(3',3'-Dimethylsuccinyl)betulinic acid, 3-O-(3',3'-dimethylsuccinyl) betulinic acid, (3beta)-3-[(3-carboxy-3-methylbutanoyl)oxy]lup-20(29)-en-28-oic acid, (3beta)-3-((3-carboxy-3-methylbutanoyl)oxy)lup-20(29)-en-28-oic acid, dsb-2nmg, Bevirimat [INN], BVM, O-(3,3-Dimethylsuccinyl)betulinic acid