Products 175414-77-4
CAS 175414-77-4 appears in our catalog under these names: Voreloxin, Voreloxin, 99.85%, Voreloxin, min. 95 %, 2 mg, Voreloxin, min. 95 %, 5 mg, Voreloxin, min. 95 %, 10 mg. Offered by: GLPBio, TargetMol, Biosynth, MedChemExpress, Roth. Available pack sizes: 10mg, 25mg, 5mg, 10mM (in 1ml dmso), 1mg, 2mg, 10mM/1mL, 50 mg.
Vosaroxin is a 1,8-naphthyridine derivative that is 1,8-naphthyridin-4(1H)-one substituted by 1,3-thiazol-2-yl, carboxy, and (3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl groups at positions 1, 3, and 7, respectively. It targets topoisomerase II and induces site-selective double-strand breaks in DNA, leading to apoptosis in cancer cells. It has a role as a radiosensitizing agent, a topoisomerase II inhibitor, an intercalator, an antineoplastic agent and an apoptosis inducer. It is a quinolone, a monocarboxylic acid, an ether, a member of pyrrolidines, a member of 1,3-thiazoles, a cyclic ketone, a secondary amino compound and a 1,8-naphthyridine derivative.
Source: ChEBI
| Molecular formula | C18H19N5O4S |
|---|---|
| Molecular weight | 401.4 g/mol |
| IUPAC name | 7-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,8-naphthyridine-3-carboxylic acid |
| InChIKey | XZAFZXJXZHRNAQ-STQMWFEESA-N |
| SMILES | CN[C@H]1CN(C[C@@H]1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(=O)O |
Computed by PubChem (NCBI)