CAS 196309-76-9 appears in our catalog under these names: BAY 11-7085, >95% (HPLC), Bay 11-7085/ 99.83% (existing batch purity), Bay 11–7085, BAY 11-7085, >97.0%(N), Bay 11-7085. Offered by: TRC, TargetMol, GLPBio, TCI, Biosynth. Available pack sizes: 25mg, 5mg, 2mg, 10mg, 50mg, 100mg, 200mg, 10mM (in 1ml dmso).
BAY11-7085 is a sulfone that is benzene substituted by [(E)-2-cyanoethenyl]sulfonyl and tert-butyl groups at position 1 and 4, respectively. It is an irreversible inhibitor of IB-alpha phosphorylation in cells (IC50 = 10 M) and prevents the activation of NF-B. It has a role as an autophagy inducer, a ferroptosis inducer, an antibacterial agent, an antineoplastic agent, an anti-inflammatory agent, an apoptosis inducer, a NF-kappaB inhibitor and an EC 2.7.11.10 (IkappaB kinase) inhibitor. It is a nitrile, a member of benzenes and a sulfone.
Source: ChEBI
| Molecular formula | C13H15NO2S |
|---|---|
| Molecular weight | 249.33 g/mol |
| IUPAC name | (E)-3-(4-tert-butylphenyl)sulfonylprop-2-enenitrile |
| InChIKey | VHKZGNPOHPFPER-ONNFQVAWSA-N |
| SMILES | CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)/C=C/C#N |
Computed by PubChem (NCBI)