Products 1998725-11-3
CAS 1998725-11-3 appears in our catalog under these names: JHU-083, JHU-083, 99.38%, L-Norleucine, L-leucyl-6-diazo-5-oxo-, ethyl ester. Offered by: Biosynth, MedChemExpress, Chemat. Available pack sizes: 5mg, 25mg, 10mg, 50mg, 5 mg, 100 mg, 1 mg, 10 mg.
JHU083 is an ethyl ester resulting from the formal condensation of the carboxy group of L-leucyl-6-diazo-5-oxo-L-norleucine with ethanol. It is a glutaminase inhibitor and a prodrug of 6-diazo-5-oxo-L-norleucine that exhibits antineoplastic activity. It has a role as an antineoplastic agent, a prodrug and an EC 3.5.1.2 (glutaminase) inhibitor. It is a secondary carboxamide, a ketone, an ethyl ester, a L-leucine derivative and a diazo compound.
Source: ChEBI
| Molecular formula | C14H24N4O4 |
|---|---|
| Molecular weight | 312.36 g/mol |
| IUPAC name | ethyl (2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-6-diazo-5-oxohexanoate |
| InChIKey | YZRCHOFKIPHQBW-RYUDHWBXSA-N |
| SMILES | CCOC(=O)[C@H](CCC(=O)C=[N+]=[N-])NC(=O)[C@H](CC(C)C)N |
Computed by PubChem (NCBI)
Synonyms:
ethyl (2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-6-diazo-5-oxohexanoate, ethyl (2S)-2-(((2S)-2-amino-4-methylpentanoyl)amino)-6-diazo-5-oxohexanoate, ethyl (2S)-2-{[(2S)-2-amino-4-methylpentanoyl]amino}-6-diazo-5-oxohexanoate, L-Norleucine, L-leucyl-6-diazo-5-oxo-, ethyl ester, orb1707162, orb3054177, ethyl (S)-2-((S)-2-amino-4-methylpentanamido)-6-diazo-5-oxohexanoate, ethyl L-leucyl-6-diazo-5-oxo-L-norleucinate