Products 219989-84-1

CAS 219989-84-1 appears in our catalog under these names: Ixabepilone, Ixabepilone, >95% (HPLC), Ixabepilone/ 98.6% (existing batch purity), Ixabepilone 98%, (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione, 98%, 98%. Offered by: Chemat Brand, TRC, TargetMol, GLPBio, Biosynth. Available pack sizes: on request, 2,5mg, 25mg, 1mg, 2mg, 5mg, 10mg, 50mg.

Ixabepilone
Chemat Brand, GLPBio, Biosynth
  • size: on request, 5mg, 10mM (in 1ml dmso), 25mg
  • Variants: 5
from 1341.24
View product
Ixabepilone, >95% (HPLC)
TRC
  • size: 2,5mg, 25mg
  • Variants: 2
View product
Ixabepilone/ 98.6% (existing batch purity)
TargetMol
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 8
from 525.34
View product
Ixabepilone 98%
Ambeed
  • size: 100mg, 1mg, 5mg, 10mg
  • Variants: 6
from 476.06
View product
(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione, 98%, 98%
Chemat
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 5
from 290.00
View product
Ixabepilone (Standard)
MedChemExpress
  • size: Get quote
  • Variants: 1
View product
Ixabepilone, 99.93%
MedChemExpress
  • size: 10mM/1mL, 10 mg, 5 mg, 1 mg
  • Variants: 4
from 691.21
View product
IXABEPILONE, 98%
Fluorochem
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 5
from 476.93
View product
Structural formula: {0} (CAS {1})

Ixabepilone is a macrocycle that is a lactam analogue of epothilone B. Binds directly to beta-tubulin subunits on microtubules, leading to suppression of microtubule dynamics. It has a role as an antineoplastic agent and a microtubule-destabilising agent. It is a lactam, an epoxide, a member of 1,3-thiazoles, a macrocycle and a beta-hydroxy ketone.

Source: ChEBI

Identity
Molecular formulaC27H42N2O5S
Molecular weight506.7 g/mol
IUPAC name(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
InChIKeyFABUFPQFXZVHFB-PVYNADRNSA-N
SMILESC[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](NC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C

Computed by PubChem (NCBI)

Synonyms: Ixabepilone, Azaepothilone B, Ixempra, Aza-epothilone B, Ixempra kit, ixabepilona, ixabepilonum, Epothilone-B BMS 247550, Ixabepilone [INN], Ixempra (TN)
Related forms of this compound
(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(Z)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione C27H42N2O5S
(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-[2-(trideuteriomethyl)-1,3-thiazol-4-yl]prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione C27H42N2O5S
Isomers (same molecular formula)
(1R,2R,6S,7S,8R,11S,15S)-2,7,11-trihydroxy-2,6,8,10,10-pentamethyl-15-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-14-azabicyclo[11.3.1]heptadec-13-en-9-one C27H42N2O5S
(1S,2R,6S,7S,8R,11S,15S)-2,7,11-trihydroxy-2,6,8,10,10-pentamethyl-15-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-14-azabicyclo[11.3.1]heptadec-13-en-9-one C27H42N2O5S