Products 253128-41-5
CAS 253128-41-5 appears in our catalog under these names: Eribulin, Eribulin/ 99.96% (existing batch purity), Eribulin 99%, Eribulin, 99%, 99%, Eribulin, 99.92%. Offered by: GLPBio, Chemat Brand, TargetMol, Ambeed, Chemat. Available pack sizes: 500μg, on request, 1mg, 5mg, 10mg, 25mg, 50mg, 100 mg.
Eribulin is a fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mechanism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage. It has a role as an antineoplastic agent and a microtubule-destabilising agent. It is a polycyclic ether, a cyclic ketone, a polyether, a primary amino compound, a macrocycle and a cyclic ketal. It is a conjugate base of an eribulin(1+).
Source: ChEBI
| Molecular formula | C40H59NO11 |
|---|---|
| Molecular weight | 729.9 g/mol |
| IUPAC name | (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.13,32.13,33.16,9.112,16.018,22.029,36.031,35]hentetracontan-24-one |
| InChIKey | UFNVPOGXISZXJD-JBQZKEIOSA-N |
| SMILES | C[C@@H]1C[C@@H]2CC[C@H]3C(=C)C[C@@H](O3)CC[C@]45C[C@@H]6[C@H](O4)[C@H]7[C@@H](O6)[C@@H](O5)[C@@H]8[C@@H](O7)CC[C@@H](O8)CC(=O)C[C@H]9[C@H](C[C@H](C1=C)O2)O[C@@H]([C@@H]9OC)C[C@@H](CN)O |
Computed by PubChem (NCBI)