Products 253310-42-8

CAS 253310-42-8 appears in our catalog under these names: BMS 195614/ 97.7% (existing batch purity), BMS 195614, ≥97%, ≥97%. Offered by: TargetMol, Chemat. Available pack sizes: 1mg, 5mg, 10mg, 25mg, 50mg, 100mg, 500mg, 250mg.

BMS 195614/ 97.7% (existing batch purity)
TargetMol
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 7
from 1335.33
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BMS 195614, ≥97%, ≥97%
Chemat
  • size: 10mg, 50mg, 250mg
  • Variants: 3
from 477.20
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Structural formula: {0} (CAS {1})

BMS 195614 is a carboxamide resulting from the formal condensation of the carboxy group of 5,5-dimethyl-8-(quinolin-3-yl)-5,6-dihydronaphthalene-2-carboxylic acid with the amino group of p-aminobenzoic acid. It is a neutral retinoic acid receptor (RAR) alpha-selective antagonist (Ki = 2.5 nM). It displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. It antagonizes agonist-induced coactivator (CoA) recruitment. It has a role as a retinoic acid receptor alpha antagonist. It is a secondary carboxamide, a member of benzoic acids and a member of quinolines.

Source: ChEBI

Identity
Molecular formulaC29H24N2O3
Molecular weight448.5 g/mol
IUPAC name4-[(5,5-dimethyl-8-quinolin-3-yl-6H-naphthalene-2-carbonyl)amino]benzoic acid
InChIKeyWGLMBRZXZDAQHP-UHFFFAOYSA-N
SMILESCC1(CC=C(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)C4=CC5=CC=CC=C5N=C4)C

Computed by PubChem (NCBI)

Synonyms: 4-[(5,5-dimethyl-8-quinolin-3-yl-6H-naphthalene-2-carbonyl)amino]benzoic acid, 4-[(5,5-dimethyl-8-quinolin-3-yl6H-naphthalene-2-carbonyl)amino]benzoic acid, orb1704871, orb1785921, 4-[[5,5-dimethyl-8-(3-quinolyl)-6H-naphthalene-2-carbonyl]amino]benzoic acid
Related forms of this compound
4-[(5,5-dimethyl-8-quinolin-3-yl-6H-naphthalene-2-carbonyl)amino]benzoic acid C29H24N2O3