Products 265121-04-8

CAS 265121-04-8 appears in our catalog under these names: Fosaprepitant Dimeglumine, Fosaprepitant Dimeglumine, >95% (HPLC), Fosaprepitant dimeglumine/ 97.39% (existing batch purity), Fosaprepitant dimeglumine salt, 1-Deoxy-1-(methylamino)-D-glucitol (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)m ethyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)phosphonate. Offered by: Chemat Brand, TRC, TargetMol, GLPBio, Biosynth. Available pack sizes: on request, 100mg, 10mg, 25mg, 5mg, 50mg, 10mM (in 1ml dmso), 250mg.

Fosaprepitant Dimeglumine
Chemat Brand
  • size: on request
  • Variants: 1
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Fosaprepitant Dimeglumine, >95% (HPLC)
TRC
  • size: 100mg, 10mg, 25mg
  • Variants: 3
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Fosaprepitant dimeglumine/ 97.39% (existing batch purity)
TargetMol
  • size: 5mg, 10mg, 25mg, 50mg
  • Variants: 5
from 478.94
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Fosaprepitant dimeglumine salt
GLPBio
  • size: 10mg, 25mg, 5mg, 10mM (in 1ml dmso)
  • Variants: 5
from 648.53
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1-Deoxy-1-(methylamino)-D-glucitol (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)m ethyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)phosphonate
Biosynth
  • size: 250mg, 100mg, 500mg, 1000mg
  • Variants: 5
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Fosaprepitant Dimeglumine, >95.0%(HPLC)(qNMR)
TCI
  • size: 100mg
  • Variants: 1
from 532.88
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Fosaprepitant Dimeglumine 98% （HNMR）
Ambeed
  • size: 250mg, 1g, 5g
  • Variants: 3
from 370.38
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Fosaprepitant (dimeglumine), 99.0%
MedChemExpress
  • size: 5 mg, 10 mg, 50 mg, 100 mg
  • Variants: 4
from 384.71
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Fosaprepitant (dimeglumine) (Standard)
MedChemExpress
  • size: 5 mg, 10 mg, 100 mg, 50 mg
  • Variants: 5
from 784.09
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Fosaprepitant dimeglumine, 98%
Fluorochem
  • size: 250mg, 1g, 5g, 25g
  • Variants: 4
from 341.56
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Structural formula: {0} (CAS {1})

Fosaprepitant dimeglumine is an organoammonium salt obtained by reaction of fosaprepitant with two equivalents of 1-deoxy-1-(methylamino)-D-glucitol. A substance P/neurokinin 1 (NK1) receptor antagonist. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting and postoperative nausea and vomiting. It has a role as a prodrug, an antiemetic and a neurokinin-1 receptor antagonist. It contains a fosaprepitant(2-).

Source: ChEBI

Identity
Molecular formulaC37H56F7N6O16P
Molecular weight1004.8 g/mol
IUPAC name[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4H-1,2,4-triazol-1-yl]phosphonic acid;bis((2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol)
InChIKeyVRQHBYGYXDWZDL-OOZCZQCLSA-N
SMILESC[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NN(C(=O)N3)P(=O)(O)O)C4=CC=C(C=C4)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

Computed by PubChem (NCBI)

Synonyms: Fosaprepitant dimeglumine, Fosaprepitant meglumine, Ivemend, FOCINVEZ, Emend for injection, Fosaprepitant dimeglumine salt, Fosaprepitant dimeglumine [USAN], Fosaprepitant (dimeglumine), Fosaprepitant meglumine (JAN), Fosaprepitant dimeglumine (USAN)
Related forms of this compound
[3-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4H-1,2,4-triazol-1-yl]phosphonic acid;bis((2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol) C37H56F7N6O16P