Products 302962-49-8
CAS 302962-49-8 appears in our catalog under these names: Dasatinib, Dasatinib, >95% (HPLC), Dasatinib/ 99.89% (existing batch purity), Dasatinib (BMS–354825), Dasatinib - Bio-X â„¢. Offered by: Chemat Brand, TRC, TargetMol, GLPBio, Biosynth. Available pack sizes: on request, 1g, 2,5g, 500mg, 50mg, 100mg, 200mg, 10mM (in 1ml dmso).
Dasatinib (anhydrous) is an aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN). It has a role as an anticoronaviral agent, an antineoplastic agent and a tyrosine kinase inhibitor. It is a monocarboxylic acid amide, an organochlorine compound, an aminopyrimidine, a member of 1,3-thiazoles, a N-arylpiperazine, a N-(2-hydroxyethyl)piperazine, a secondary amino compound and a tertiary amino compound. It is a conjugate base of a dasatinib(1+).
Source: ChEBI
| Molecular formula | C22H26ClN7O2S |
|---|---|
| Molecular weight | 488.0 g/mol |
| IUPAC name | N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide |
| InChIKey | ZBNZXTGUTAYRHI-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO |
Computed by PubChem (NCBI)