Products 432531-71-0

CAS 432531-71-0 appears in our catalog under these names: Necrosulfonamide, (E/Z)-Necrosulfonamide/ min. 98%, (E/Z)–Necrosulfonamide, MLKL Inhibitor, Necrosulfonamide, (E/Z)-Necrosulfonamide 98%. Offered by: TRC, TargetMol, GLPBio, Biosynth, Ambeed. Available pack sizes: 100mg, 10mg, 1mg, 2mg, 5mg, 25mg, 50mg, 0,5g.

Necrosulfonamide
TRC
  • size: 100mg, 10mg, 1mg
  • Variants: 3
View product
(E/Z)-Necrosulfonamide/ min. 98%
TargetMol
  • size: 2mg, 5mg, 10mg, 25mg
  • Variants: 6
from 405.71
View product
(E/Z)–Necrosulfonamide
GLPBio
  • size: 10mg, 100mg, 25mg, 5mg
  • Variants: 5
from 681.29
View product
MLKL Inhibitor, Necrosulfonamide
Biosynth
  • size: 0,5g, 50mg
  • Variants: 2
View product
(E/Z)-Necrosulfonamide 98%
Ambeed
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 8
from 175.69
View product
(E/Z)-Necrosulfonamide, 98%, 98%
Chemat
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 7
from 155.60
View product
(E/Z)-Necrosulfonamide, 98.03%
MedChemExpress
  • size: 50 mg, 10 mg, 25 mg, 5 mg
  • Variants: 5
from 505.45
View product
N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide, 98%
Fluorochem
  • size: 250mg
  • Variants: 1
from 3673.72
View product
Structural formula: {0} (CAS {1})

Necrosulfonamide is a sulfonamide that is a 3-methoxypyrazin-2-yl derivative of (E)-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide. Necrosulfonamide specifically blocks necrosis downstream of the activation of RIP3 (the receptor-interacting serine-threonine kinase 3), a key signalling molecule in the programmed necrosis (necroptosis) pathway. It has a role as a necroptosis inhibitor and a neuroprotective agent. It is a member of thiophenes, a sulfonamide and a member of pyrazines.

Source: ChEBI

Identity
Molecular formulaC18H15N5O6S2
Molecular weight461.5 g/mol
IUPAC name(E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide
InChIKeyFNPPHVLYVGMZMZ-XBXARRHUSA-N
SMILESCOC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(S3)[N+](=O)[O-]

Computed by PubChem (NCBI)

Synonyms: Necrosulfonamide, (E/Z)-Necrosulfonamide, Necrosulfonarnide, Necrosulfonamide (NSA)?, orb1220501, orb1226452, orb1300359, MLKL Inhibitor, Necrosulfonamide
Related forms of this compound
(E)-3-(5-nitrothiophen-2-yl)-N-[2,3,5,6-tetradeuterio-4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]prop-2-enamide C18H15N5O6S2