Products 488-04-0
CAS 488-04-0 appears in our catalog under these names: Holomycin, >95% (HPLC), Holomycin/ 98.09% (existing batch purity), Holomycin, 95.09%. Offered by: TRC, TargetMol, MedChemExpress. Available pack sizes: 2,5mg, 25mg, 1mg, 5mg, 10mg, 50mg, 100mg, 1 mg.
Holomycin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties. It has a role as an antibacterial agent, an antineoplastic agent, an EC 2.7.7.6 (RNA polymerase) inhibitor, a chelator, a marine metabolite and a bacterial metabolite. It is a dithiolopyrrolone antibiotic and a member of acetamides.
Source: ChEBI
| Molecular formula | C7H6N2O2S2 |
|---|---|
| Molecular weight | 214.3 g/mol |
| IUPAC name | N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide |
| InChIKey | HBUNPJGMNVQSBX-UHFFFAOYSA-N |
| SMILES | CC(=O)NC1=C2C(=CSS2)NC1=O |
Computed by PubChem (NCBI)
Synonyms:
HOLOMYCIN, N-Demethylthiolutin, N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide, N-(4,5-Dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide, 6-Acetamido-1,2-dithiolo(4,3-b)pyrrol-5(4H)-one, N-(4,5-Dihydro-5-oxo-1,2-dithiolo(4,3-b)pyrrol-6-yl)acetamide, N-(4,5-Dihydro-5-oxo-1,2-dithiolo-(4,3-b)pyrrol-6-yl)acetamide, 6-acetamido-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one, N-(5-oxo-4H-Dithiolo(4,3-b)pyrrol-6-yl)acetamide, N-(4,5-dihydro-5-oxo-1,2-dithiolo-[4,3-b]pyrrol-6-yl)acetamide