CAS 67469-78-7 appears in our catalog under these names: GBR-12909 Dihydrochloride, >95% (HPLC), Vanoxerine dihydrochloride, Vanoxerine dihydrochloride, GBR 12909 dihydrochloride , GBR 12909 dihydrochloride. Offered by: TRC, TargetMol, GLPBio, Thermo Scientific (Alfa Aesar), Biosynth. Available pack sizes: 10mg, 50mg, 5mg, 25mg, 100mg, 10mM (in 1ml dmso), 250mg, 500mg.
Vanoxerine dihydrochloride is a hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration. It has a role as a dopamine uptake inhibitor. It contains a vanoxerine(2+).
Source: ChEBI
| Molecular formula | C28H34Cl2F2N2O |
|---|---|
| Molecular weight | 523.5 g/mol |
| IUPAC name | 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine;dihydrochloride |
| InChIKey | MIBSKSYCRFWIRU-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl |
Computed by PubChem (NCBI)