Products 783355-60-2
CAS 783355-60-2 appears in our catalog under these names: PCI-24781, PCI–24781 (CRA–024781), Abexinostat/ 98.39% (existing batch purity), PCI 24781, Abexinostat 98%. Offered by: TRC, GLPBio, TargetMol, Biosynth, Ambeed. Available pack sizes: 100mg, 10mg, 200mg, 5mg, 10mM (in 1ml dmso), 50mg, 1mg, 2mg.
Abexinostat is a 1-benzofuran substituted by {2-[4-(hydroxycarbamoyl)phenoxy]ethyl}aminocarbonyl and (dimethylamino)methyl groups at positions 2 and 3, respectively. It is a potent pan-HDAC inhibitor whose major target is HDAC1 (Ki = 7 nM). It has a role as a radiosensitizing agent, an autophagy inducer, an antineoplastic agent, an EC 3.5.1.98 (histone deacetylase) inhibitor and an apoptosis inducer. It is a secondary carboxamide, a hydroxamic acid, an aromatic ether, a member of 1-benzofurans and a tertiary amino compound.
Source: ChEBI
| Molecular formula | C21H23N3O5 |
|---|---|
| Molecular weight | 397.4 g/mol |
| IUPAC name | 3-[(dimethylamino)methyl]-N-[2-[4-(hydroxycarbamoyl)phenoxy]ethyl]-1-benzofuran-2-carboxamide |
| InChIKey | MAUCONCHVWBMHK-UHFFFAOYSA-N |
| SMILES | CN(C)CC1=C(OC2=CC=CC=C21)C(=O)NCCOC3=CC=C(C=C3)C(=O)NO |
Computed by PubChem (NCBI)