Products 915019-65-7

CAS 915019-65-7 appears in our catalog under these names: Dactolisib (NVP-BEZ 235), NVP-BEZ 235, Dactolisib/ 99.71% (existing batch purity), BEZ235 (NVP–BEZ235), NVP-BEZ235. Offered by: Chemat Brand, TRC, TargetMol, GLPBio, Chemat. Available pack sizes: on request, 10mg, 25mg, 50mg, 100mg, 200mg, 500mg, 5mg.

Dactolisib (NVP-BEZ 235)
Chemat Brand
  • size: on request
  • Variants: 1
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NVP-BEZ 235
TRC
  • size: 10mg, 25mg, 50mg
  • Variants: 3
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Dactolisib/ 99.71% (existing batch purity)
TargetMol
  • size: 25mg, 50mg, 100mg, 200mg
  • Variants: 4
from 445.96
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BEZ235 (NVP–BEZ235)
GLPBio
  • size: 10mg, 100mg, 200mg, 50mg
  • Variants: 5
from 545.55
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NVP-BEZ235
Chemat
  • size: 25mg, 5mg
  • Variants: 2
from 396.71
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NVP BEZ 235
Biosynth
  • size: 50mg, 10mg
  • Variants: 2
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Dactolisib 98+%
Ambeed
  • size: 1mg, 10mg, 50mg, 100mg
  • Variants: 6
from 142.31
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2-Methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile, 98+%, 98+%
Chemat
  • size: 10mg, 25mg, 50mg, 100mg
  • Variants: 7
from 83.60
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Dactolisib, 99.94%
MedChemExpress
  • size: 100 mg, 200 mg, 50 mg, 500 mg
  • Variants: 4
from 435.79
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Structural formula: {0} (CAS {1})

Dactolisib is an imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment. It has a role as an antineoplastic agent, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and a mTOR inhibitor. It is a nitrile, a member of quinolines, a ring assembly, an imidazoquinoline and a member of ureas.

Source: ChEBI

Identity
Molecular formulaC30H23N5O
Molecular weight469.5 g/mol
IUPAC name2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile
InChIKeyJOGKUKXHTYWRGZ-UHFFFAOYSA-N
SMILESCC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5

Computed by PubChem (NCBI)

Synonyms: dactolisib, dactolisibum, Dactolisib (BEZ235), CT-BEZ, Dactolisib [USAN], Dactolisib [USAN:INN], 915019-65-7 (free base), Kinome_2911, DACTOLISIB [INN], Dactolisib (USAN/INN)
Related forms of this compound
2-methyl-2-[4-[2-oxo-8-quinolin-3-yl-3-(trideuteriomethyl)imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile C30H23N5O