CAS 918505-84-7 appears in our catalog under these names: PLX–4720, PLX-4720/ 99.83% (existing batch purity), PLX4720, PLX 4720, n-[3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide, 99+%, 99+%. Offered by: GLPBio, TargetMol, Chemat, Biosynth, MedChemExpress. Available pack sizes: 10mg, 100mg, 25mg, 10mM (in 1ml dmso), 5mg, 50mg, 250mg, 1mg.
PLX-4720 is a pyrrolopyridine that is vemurafenib in which the p-chlorophenyl group has been replaced by chlorine. It is a potent and selective inhibitor of the Raf kinase B-Raf(V600E). It has a role as an antineoplastic agent and a B-Raf inhibitor. It is a sulfonamide, an organochlorine compound, a difluorobenzene, a pyrrolopyridine and an aromatic ketone.
Source: ChEBI
| Molecular formula | C17H14ClF2N3O3S |
|---|---|
| Molecular weight | 413.8 g/mol |
| IUPAC name | N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide |
| InChIKey | YZDJQTHVDDOVHR-UHFFFAOYSA-N |
| SMILES | CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)Cl)F |
Computed by PubChem (NCBI)